SGK1

SGK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2R5T, 3HDM, 3HDN
Dynodwyr
Cyfenwau	SGK1, SGK, serum/glucocorticoid regulated kinase 1
Dynodwyr allanol	OMIM: 602958 HomoloGene: 48364 GeneCards: SGK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • sodium channel regulator activity • calcium channel regulator activity • kinase activity • potassium channel regulator activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • chloride channel regulator activity • ATP binding • protein serine/threonine kinase activity Cydrannau o'r gell • endoplasmic reticulum membrane • bilen • Cellbilen • Reticwlwm endoplasmig • mitocondria • cnewyllyn cell • cytoplasm • cytosol • nuclear speck Prosesau biolegol • regulation of apoptotic process • GO:0007243 intracellular signal transduction • regulation of cell migration • positive regulation of transporter activity • phosphorylation • sodium ion transport • cellular response to DNA damage stimulus • regulation of blood pressure • protein phosphorylation • cludo transmembrane rhwng ïonau • regulation of cell population proliferation • regulation of DNA-binding transcription factor activity • regulation of cell growth • GO:0048552 regulation of catalytic activity • renal sodium ion absorption • regulation of gastric acid secretion • GO:0097285 apoptotic process • GO:0035404 peptidyl-serine phosphorylation • long-term memory • neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6446	n/a
Ensembl	ENSG00000118515	n/a
UniProt	O00141	n/a
RefSeq (mRNA)	NM_001143676 NM_001143677 NM_001143678 NM_001291995 NM_005627	n/a
RefSeq (protein)	NP_001137148 NP_001137149 NP_001137150 NP_001278924 NP_005618	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SGK1 yw SGK1 a elwir hefyd yn Serine/threonine-protein kinase Sgk1 a Serum/glucocorticoid regulated kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q23.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SGK1.

• SGK

Llyfryddiaeth

• "Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia. ". Radiat Oncol. 2016. PMID 27251632.
• "SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism. ". Mol Cancer Res. 2016. PMID 26869290.
• "Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics. ". Acta Biochim Biophys Sin (Shanghai). 2017. PMID 28338770.
• "The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells. ". J Cell Physiol. 2017. PMID 28177128.
• "SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.". Cell Physiol Biochem. 2016. PMID 27771704.