SF3B1

SF3B1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2F9D, 2F9J, 2PEH, 3LQV, 4OZ1, 2FHO
Dynodwyr
Cyfenwau	SF3B1, Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155, splicing factor 3b subunit 1
Dynodwyr allanol	OMIM: 605590 HomoloGene: 6696 GeneCards: SF3B1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • mRNA binding • RNA binding Cydrannau o'r gell • U11/U12 snRNP • catalytic step 2 spliceosome • spliceosomal complex • U12-type spliceosomal complex • U2-type prespliceosome • cnewyllyn cell • U2 snRNP • nucleoplasm • nuclear speck • U2-type precatalytic spliceosome Prosesau biolegol • RNA splicing, via transesterification reactions • epigenetic maintenance of chromatin in transcription-competent conformation • mRNA splicing, via spliceosome • spliceosomal complex assembly • mRNA processing • RNA splicing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23451	n/a
Ensembl	ENSG00000115524	n/a
UniProt	O75533	n/a
RefSeq (mRNA)	NM_001005526 NM_001308824 NM_012433	n/a
RefSeq (protein)	NP_001005526 NP_001295753 NP_036565	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SF3B1 yw SF3B1 a elwir hefyd yn Splicing factor 3b subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SF3B1.

• MDS
• PRP10
• Hsh155
• PRPF10
• SAP155
• SF3b155

Llyfryddiaeth

• "SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity. ". PLoS One. 2017. PMID 28445500.
• "Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. ". Cancer Cell. 2016. PMID 27818134.
• "SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells. ". Blood. 2017. PMID 28634182.
• "Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR. ". Clin Chem. 2017. PMID 28615231.
• "Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.". Int J Hematol. 2017. PMID 28466384.