SF3A1

SF3A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZKH, 2DT6, 2DT7
Dynodwyr
Cyfenwau	SF3A1, PRP21, PRPF21, SAP114, SF3A120, splicing factor 3a subunit 1
Dynodwyr allanol	OMIM: 605595 HomoloGene: 4294 GeneCards: SF3A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • RNA binding Cydrannau o'r gell • catalytic step 2 spliceosome • spliceosomal complex • U2-type spliceosomal complex • U2-type prespliceosome • cnewyllyn cell • nucleoplasm • nuclear speck • U2 snRNP • U2-type precatalytic spliceosome Prosesau biolegol • mRNA splicing, via spliceosome • mRNA processing • GO:0033168, GO:0036404, GO:1902360 RNA processing • mRNA 3'-splice site recognition • RNA splicing • regulation of alternative mRNA splicing, via spliceosome • U2-type prespliceosome assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10291	n/a
Ensembl	ENSG00000099995	n/a
UniProt	Q15459	n/a
RefSeq (mRNA)	NM_005877 NM_001005409	n/a
RefSeq (protein)	NP_005868	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SF3A1 yw SF3A1 a elwir hefyd yn Splicing factor 3a subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q12.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SF3A1.

• PRP21
• PRPF21
• SAP114
• SF3A120

Llyfryddiaeth

• "Structure and assembly of the SF3a splicing factor complex of U2 snRNP. ". EMBO J. 2012. PMID 22314233.
• "Interaction domains and nuclear targeting signals in subunits of the U2 small nuclear ribonucleoprotein particle-associated splicing factor SF3a. ". J Biol Chem. 2011. PMID 21349847.
• "SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. ". Oncotarget. 2015. PMID 26498691.
• "The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population. ". PLoS One. 2015. PMID 26079486.
• "Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly.". Genes Dev. 2014. PMID 25403181.