SF1

SF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1K1G, 1O0P, 1OPI, 2M09, 4FXW, 4FXX
Dynodwyr
Cyfenwau	SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1
Dynodwyr allanol	OMIM: 601516 HomoloGene: 138518 GeneCards: SF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • identical protein binding • pre-mRNA branch point binding • RNA binding Cydrannau o'r gell • ribosom • spliceosomal complex • cnewyllyn cell • nucleoplasm • nuclear body Prosesau biolegol • negative regulation of smooth muscle cell proliferation • GO:0009373 regulation of transcription, DNA-templated • Leydig cell differentiation • mRNA processing • regulation of steroid biosynthetic process • male sex determination • transcription, DNA-templated • spliceosomal complex assembly • mRNA 3'-splice site recognition • RNA splicing • negative regulation of nucleic acid-templated transcription • mRNA splicing, via spliceosome • nuclear body organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7536	n/a
Ensembl	ENSG00000168066	n/a
UniProt	Q15637	n/a
RefSeq (mRNA)	NM_001178030 NM_001178031 NM_004630 NM_201995 NM_201997 NM_201998 NM_001346363 NM_001346364 NM_001346409 NM_001346410 NM_001378956 NM_001378957	n/a
RefSeq (protein)	NP_001171501 NP_001171502 NP_001333292 NP_001333293 NP_001333338 NP_001333339 NP_004621 NP_973724 NP_973726 NP_973727 NP_001365885 NP_001365886	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SF1 yw SF1 a elwir hefyd yn Splicing factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SF1.

• BBP
• MBBP
• ZFM1
• ZNF162
• D11S636
• ZCCHC25

Llyfryddiaeth

• "Zinc finger motif-1 antagonizes PDGF-BB-induced growth and dedifferentiation of vascular smooth muscle cells. ". FASEB J. 2012. PMID 22906951.
• "Purification, crystallization and preliminary X-ray crystallographic analysis of a central domain of human splicing factor 1. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID 21505248.
• "SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3'-Splice-Site RNA. ". Biophys J. 2016. PMID 28002734.
• "SF1 immunohistochemistry is useful in differentiating uterine tumours resembling sex cord-stromal tumours from potential histological mimics. ". Pathology. 2016. PMID 27311867.
• "Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction.". Proteins. 2014. PMID 25043850.