SETMAR

SETMAR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3BO5, 3F2K, 3K9J, 3K9K
Dynodwyr
Cyfenwau	SETMAR, HsMar1, METNASE, Mar1, SET domain and mariner transposase fusion gene
Dynodwyr allanol	OMIM: 609834 HomoloGene: 121979 GeneCards: SETMAR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • protein homodimerization activity • zinc ion binding • histone methyltransferase activity (H3-K4 specific) • histone-lysine N-methyltransferase activity • metal ion binding • single-stranded DNA binding • single-stranded DNA endodeoxyribonuclease activity • DNA topoisomerase binding • GO:0001948, GO:0016582 protein binding • catalytic activity • nuclease activity • endonuclease activity • histone methyltransferase activity (H3-K36 specific) • double-stranded DNA binding • hydrolase activity • DNA binding Cydrannau o'r gell • site of double-strand break • Cromosom • condensed chromosome • cnewyllyn cell • nucleolus Prosesau biolegol • histone H3-K36 dimethylation • DNA integration • nucleic acid phosphodiester bond hydrolysis • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity • DNA double-strand break processing • positive regulation of double-strand break repair via nonhomologous end joining • DNA catabolic process, endonucleolytic • cellular response to DNA damage stimulus • histone H3-K36 methylation • histone H3-K4 methylation • methylation • replication fork processing • histone lysine methylation • mitotic DNA integrity checkpoint signaling • metabolaeth • cell population proliferation • double-strand break repair via nonhomologous end joining • negative regulation of chromosome organization • GO:0100026 DNA repair • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6419	n/a
Ensembl	ENSG00000170364	n/a
UniProt	Q53H47	n/a
RefSeq (mRNA)	NM_001243723 NM_001276325 NM_006515 NM_001320676 NM_001320677 NM_001320678	n/a
RefSeq (protein)	NP_001230652 NP_001263254 NP_001307605 NP_001307606 NP_001307607 NP_006506	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SETMAR yw SETMAR a elwir hefyd yn SET domain and mariner transposase fusion gene (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SETMAR.

• 36951
• METNASE

Llyfryddiaeth

• "Delineation of known and new transcript variants of the SETMAR (Metnase) gene and the expression profile in hematologic neoplasms. ". Exp Hematol. 2014. PMID 24607956.
• "Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity. ". Biochemistry. 2007. PMID 17877369.
• "The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5' End of SS-Overhang Cleavage. ". PLoS One. 2015. PMID 26437079.
• "Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes. ". PLoS One. 2014. PMID 25333365.
• "Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing.". BMC Mol Biol. 2014. PMID 24655462.