SERPINI1

SERPINI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3F02, 3F5N, 3FGQ
Dynodwyr
Cyfenwau	SERPINI1, PI12, neuroserpin, serpin family I member 1, HNS-S2, HNS-S1
Dynodwyr allanol	OMIM: 602445 HomoloGene: 21045 GeneCards: SERPINI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • extracellular region • extracellular exosome • secretory granule lumen • neuronal cell body • cytoplasmic vesicle lumen • extracellular space • GO:0016023 cytoplasmic vesicle • perikaryon Prosesau biolegol • central nervous system development • negative regulation of peptidase activity • regulation of cell adhesion • peripheral nervous system development • negative regulation of endopeptidase activity • positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5274	n/a
Ensembl	ENSG00000163536	n/a
UniProt	Q99574	n/a
RefSeq (mRNA)	NM_005025 NM_001122752	n/a
RefSeq (protein)	NP_001116224 NP_005016	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINI1 yw SERPINI1 a elwir hefyd yn Serpin family I member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINI1.

• PI12
• neuroserpin

Llyfryddiaeth

• "The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop. ". Sci Rep. 2015. PMID 26329378.
• "Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics. ". Biochim Biophys Acta. 2015. PMID 25450507.
• "SERPINI1 pathogenic variants: An emerging cause of childhood-onset progressive myoclonic epilepsy. ". Am J Med Genet A. 2017. PMID 28631894.
• "SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer. ". Cancer Sci. 2016. PMID 26892864.
• "Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.". FEBS J. 2015. PMID 26367528.