SENP2

SENP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TGZ, 1TH0, 2IO0, 2IO1, 2IO2, 2IO3, 3ZO5, 5AEK
Dynodwyr
Cyfenwau	SENP2, AXAM2, SMT3IP2, SUMO1/sentrin/SMT3 specific peptidase 2, SUMO specific peptidase 2
Dynodwyr allanol	OMIM: 608261 HomoloGene: 11005 GeneCards: SENP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • SUMO-specific endopeptidase activity • protein domain specific binding Cydrannau o'r gell • cytoplasm • nuclear membrane • bilen • nuclear pore • nucleoplasm • cnewyllyn cell • cytosol • nuclear body • PML body • GO:0016023 cytoplasmic vesicle Prosesau biolegol • mRNA transport • Wnt signaling pathway • protein sumoylation • proteolysis • negative regulation of protein ubiquitination • regulation of Wnt signaling pathway • protein destabilization • protein transport • positive regulation of protein ubiquitination • positive regulation of protein phosphorylation • heart development • dorsal/ventral axis specification • protein desumoylation • negative regulation of protein binding • regulation of DNA endoreduplication • negative regulation of chromatin binding • negative regulation of DNA damage response, signal transduction by p53 class mediator • fat cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of protein metabolic process • trophoblast giant cell differentiation • labyrinthine layer development • spongiotrophoblast layer development • negative regulation of signal transduction by p53 class mediator • regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	59343	n/a
Ensembl	ENSG00000163904	n/a
UniProt	Q9HC62	n/a
RefSeq (mRNA)	NM_021627	n/a
RefSeq (protein)	NP_067640	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SENP2 yw SENP2 a elwir hefyd yn SUMO1/sentrin/SMT3 specific peptidase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q27.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SENP2.

• AXAM2
• SMT3IP2

Llyfryddiaeth

• "SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-βRI. ". Mol Carcinog. 2017. PMID 28574613.
• "Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer. ". Pathol Oncol Res. 2016. PMID 27178176.
• "SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. ". Diabetes. 2015. PMID 25784542.
• "SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of β-catenin. ". Asian Pac J Cancer Prev. 2012. PMID 23098437.
• "Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2.". Mol Cell Biol. 2006. PMID 16738331.