SEMA4D

SEMA4D
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OLZ, 3OL2
Dynodwyr
Cyfenwau	SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18
Dynodwyr allanol	OMIM: 601866 HomoloGene: 21282 GeneCards: SEMA4D
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • transmembrane signaling receptor activity • GO:0001948, GO:0016582 protein binding • semaphorin receptor binding • neuropilin binding • identical protein binding • signaling receptor activity • chemorepellent activity Cydrannau o'r gell • integral component of membrane • integral component of plasma membrane • bilen • Cellbilen • extracellular space Prosesau biolegol • regulation of dendrite morphogenesis • negative regulation of apoptotic process • positive regulation of phosphatidylinositol 3-kinase signaling • multicellular organism development • leukocyte aggregation • nervous system development • negative regulation of cell adhesion • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of axonogenesis • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis • regulation of cell projection organization • negative regulation of osteoblast differentiation • positive regulation of collateral sprouting • regulation of cell shape • negative regulation of peptidyl-tyrosine phosphorylation • cell differentiation • positive regulation of protein phosphorylation • semaphorin-plexin signaling pathway • cell adhesion • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • ossification involved in bone maturation • positive regulation of cell migration • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of alkaline phosphatase activity • negative chemotaxis • neural crest cell migration • negative regulation of axon extension involved in axon guidance • positive regulation of inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10507	n/a
Ensembl	ENSG00000187764	n/a
UniProt	Q92854	n/a
RefSeq (mRNA)	NM_001142287 NM_006378 NM_182635 NM_001371194 NM_001371195 NM_001371196 NM_001371197 NM_001371198 NM_001371199 NM_001371200 NM_001371201 NM_001371202	n/a
RefSeq (protein)	NP_001135759 NP_006369 NP_001358123 NP_001358124 NP_001358125 NP_001358126 NP_001358127 NP_001358128 NP_001358129 NP_001358130 NP_001358131	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SEMA4D yw SEMA4D a elwir hefyd yn Semaphorin-4D a Semaphorin 4D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SEMA4D.

• CD100
• COLL4
• SEMAJ
• coll-4
• C9orf164
• M-sema-G

Llyfryddiaeth

• "Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. ". J Immunol. 2016. PMID 26740106.
• "Saturation monitoring of VX15/2503, a novel semaphorin 4D-specific antibody, in clinical trials. ". Cytometry B Clin Cytom. 2016. PMID 26566052.
• "Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. ". Obesity (Silver Spring). 2017. PMID 28296344.
• "Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ). ". Biochem Biophys Res Commun. 2016. PMID 27720716.
• "Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer.". PLoS One. 2016. PMID 26910109.