SEMA3A

SEMA3A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Q47, 4GZ8, 4GZA
Dynodwyr
Cyfenwau	SEMA3A, COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1, semaphorin 3A
Dynodwyr allanol	OMIM: 603961 HomoloGene: 31358 GeneCards: SEMA3A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• chemorepellent activity; • semaphorin receptor binding; • neuropilin binding;
Cydrannau o'r gell	• extracellular region; • dendrite; • extracellular space; • axon; • integral component of plasma membrane;
Prosesau biolegol	• sympathetic ganglion development; • negative regulation of axon extension; • cell differentiation; • ventral trunk neural crest cell migration; • regulation of axon extension involved in axon guidance; • semaphorin-plexin signaling pathway involved in neuron projection guidance; • negative chemotaxis; • neural crest cell migration involved in sympathetic nervous system development; • sympathetic nervous system development; • facioacoustic ganglion development; • dendrite morphogenesis; • trigeminal ganglion development; • neuron migration; • semaphorin-plexin signaling pathway involved in axon guidance; • regulation of heart rate; • nervous system development; • axon guidance; • multicellular organism development; • sympathetic neuron projection guidance; • neural crest cell migration involved in autonomic nervous system development; • branchiomotor neuron axon guidance; • gonadotrophin-releasing hormone neuronal migration to the hypothalamus; • axonogenesis involved in innervation; • dichotomous subdivision of terminal units involved in salivary gland branching; • facial nerve structural organization; • olfactory bulb development; • motor neuron axon guidance; • axonal fasciculation; • negative regulation of epithelial cell migration; • nerve development; • trigeminal nerve structural organization; • axon extension involved in axon guidance; • semaphorin-plexin signaling pathway; • sympathetic neuron projection extension; • positive regulation of male gonad development; • sensory system development; • GO:0097285 apoptotic process; • negative regulation of neuron projection development; • negative regulation of axon extension involved in axon guidance; • positive regulation of neuron migration; • neural crest cell migration; • positive regulation of cell migration; • positive regulation of JNK cascade; • basal dendrite arborization;
	Sources:Amigo / QuickGO
Orthologau
	10371
	n/a
	ENSG00000075213
	n/a
	Q14563
	n/a
	NM_006080
	n/a
	NP_006071
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SEMA3A yw SEMA3A a elwir hefyd yn Semaphorin 3A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.11.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SEMA3A.

HH16
SemD
COLL1
SEMA1
SEMAD
SEMAL
coll-1
Hsema-I
SEMAIII
Hsema-III

Llyfryddiaeth[golygu | golygu cod]

"Decreased expression of Sema3A, an immune modulator, in blood sample of multiple sclerosis patients. ". Gene. 2017. PMID 28188869.
"Assessment of semaphorin 3A and its role in bone remodelling in a group of ankylosing spondylitis patients. ". Clin Exp Rheumatol. 2017. PMID 27782869.
"Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression. ". JAMA Psychiatry. 2017. PMID 29071344.
"Semaphorin 3A: Is a key player in the pathogenesis of asthma. ". Clin Immunol. 2017. PMID 28502680.
"The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease.". Clin Immunol. 2017. PMID 28502679.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] SEMA3A - Cronfa NCBI

[1]

[2]