SCRIB

SCRIB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UJU, 1WHA, 1X5Q, 2W4F, 4WYU, 4WYT
Dynodwyr
Cyfenwau	SCRIB, CRIB1, SCRB1, SCRIB1, Vartul, scribbled planar cell polarity protein, scribble planar cell polarity protein, oSCRIB
Dynodwyr allanol	OMIM: 607733 HomoloGene: 44228 GeneCards: SCRIB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • guanylate kinase activity • ionotropic glutamate receptor binding • cadherin binding Cydrannau o'r gell • postsynaptic membrane • cell projection • bilen • cell-cell junction • adherens junction • Cellbilen • nucleoplasm • myelin sheath abaxonal region • cell junction • cell leading edge • presynapse • extracellular exosome • presynaptic membrane • lamellipodium • Scrib-APC-beta-catenin complex • cytoplasm • cell-cell contact zone • ionotropic glutamate receptor complex • GO:0097483, GO:0097481 postsynaptic density • basolateral plasma membrane • synapse • glutamatergic synapse • extrinsic component of postsynaptic density membrane Prosesau biolegol • cell differentiation • establishment of apical/basal cell polarity • synaptic vesicle targeting • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • astrocyte cell migration • apoptotic process involved in morphogenesis • wound healing • auditory receptor cell morphogenesis • mammary gland duct morphogenesis • auditory receptor cell stereocilium organization • multicellular organism development • neural tube closure • synaptic vesicle endocytosis • protein localization to adherens junction • positive regulation of apoptotic process • positive chemotaxis • morphogenesis of embryonic epithelium • cell population proliferation • GO:0022415 viral process • cell migration • cochlear nucleus development • negative regulation of mitotic cell cycle • positive regulation of receptor recycling • chemical synaptic transmission • receptor clustering • establishment or maintenance of epithelial cell apical/basal polarity • GMP metabolic process • GDP metabolic process • receptor localization to synapse • neurotransmitter receptor transport, endosome to postsynaptic membrane • neurotransmitter receptor transport postsynaptic membrane to endosome • suppression by virus of host type I interferon-mediated signaling pathway • suppression by virus of host innate immune response • suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity • suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity • cell-cell adhesion • GO:0034613 protein localization • vesicle-mediated transport in synapse • regulation of postsynaptic neurotransmitter receptor internalization • post-anal tail morphogenesis • inner ear receptor cell stereocilium organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23513	n/a
Ensembl	ENSG00000274287 ENSG00000180900	n/a
UniProt	Q14160	n/a
RefSeq (mRNA)	NM_182706 NM_015356	n/a
RefSeq (protein)	NP_056171 NP_874365	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SCRIB yw SCRIB a elwir hefyd yn Scribbled planar cell polarity protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SCRIB.

• CRIB1
• SCRB1
• SCRIB1
• Vartul

Llyfryddiaeth

• "Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. ". Biochem J. 2015. PMID 25734361.
• "Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. ". Cancer Res. 2014. PMID 24662921.
• "APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells. ". Cell Chem Biol. 2017. PMID 28065656.
• "Expression of cell polarity protein scribble differently affects prognosis in primary tumor and lymph node metastasis of breast cancer patients. ". Breast Cancer. 2017. PMID 27562784.
• "Decreased Usage of Specific Scrib Exons Defines a More Malignant Phenotype of Breast Cancer With Worsened Survival.". EBioMedicine. 2016. PMID 27428426.