SATB1

SATB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YSE, 2L1P, 2O49, 2O4A, 3NZL, 3TUO, 2MW8
Dynodwyr
Cyfenwau	SATB1, SATB homeobox 1, DEFDA, KTZSL
Dynodwyr allanol	OMIM: 602075 HomoloGene: 2232 GeneCards: SATB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • GO:0001948, GO:0016582 protein binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • double-stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • sequence-specific DNA binding Cydrannau o'r gell • PML body • nuclear matrix • nucleoplasm • chromatin • cnewyllyn cell • nuclear body Prosesau biolegol • reflex • CD4-positive, alpha-beta T cell differentiation • CD8-positive, alpha-beta T cell differentiation • chromatin remodeling • activated T cell proliferation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • transcription, DNA-templated • epidermis development • histone methylation • GO:0022415 viral process • T cell activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6304	n/a
Ensembl	ENSG00000182568	n/a
UniProt	Q01826	n/a
RefSeq (mRNA)	NM_001131010 NM_001195470 NM_002971 NM_001322871 NM_001322872 NM_001322873 NM_001322874 NM_001322875 NM_001322876	n/a
RefSeq (protein)	NP_001124482 NP_001182399 NP_001309800 NP_001309801 NP_001309802 NP_001309803 NP_001309804 NP_001309805 NP_002962	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SATB1 yw SATB1 a elwir hefyd yn DNA-binding protein SATB1 a SATB homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p24.3.

Llyfryddiaeth

• "Analysis of cellular and molecular antitumor effects upon inhibition of SATB1 in glioblastoma cells. ". BMC Cancer. 2017. PMID 28049521.
• "SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma. ". Oral Dis. 2017. PMID 27783844.
• "Special AT-rich sequence binding protein 1 promotes tumor growth and metastasis of esophageal squamous cell carcinoma. ". Tumour Biol. 2017. PMID 28345457.
• "Tetramerization of SATB1 is essential for regulating of gene expression. ". Mol Cell Biochem. 2017. PMID 28205095.
• "SATB1 plays an oncogenic role in esophageal cancer by up-regulation of FN1 and PDGFRB.". Oncotarget. 2017. PMID 28147311.