SAP18

SAP18
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HDE
Dynodwyr
Cyfenwau	SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
Dynodwyr allanol	OMIM: 602949 HomoloGene: 4289 GeneCards: SAP18
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • GO:0001948, GO:0016582 protein binding • histone deacetylase activity • RNA binding Cydrannau o'r gell • histone deacetylase complex • nuclear speck • exon-exon junction complex • nucleoplasm • ASAP complex • cnewyllyn cell • cytoplasm • cytosol • nuclear body Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • transcription, DNA-templated • negative regulation of mRNA splicing, via spliceosome • RNA splicing • positive regulation of apoptotic process • negative regulation of nucleic acid-templated transcription • histone deacetylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10284	n/a
Ensembl	ENSG00000150459	n/a
UniProt	O00422	n/a
RefSeq (mRNA)	NM_005870 NM_001366643	n/a
RefSeq (protein)	NP_005861 NP_001353572	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SAP18 yw SAP18 a elwir hefyd yn Histone deacetylase complex subunit SAP18 a Sin3A associated protein 18 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q12.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SAP18.

• SAP18P
• 2HOR0202

Llyfryddiaeth

• "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. ". J Biol Chem. 2006. PMID 16537548.
• "INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. ". Retrovirology. 2013. PMID 23799881.
• "Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. ". Biochemistry. 2006. PMID 17002296.
• "An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability. ". J Virol. 2016. PMID 27558426.
• "Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.". J Lipid Res. 2015. PMID 25921304.