SAMHD1

SAMHD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR, 4RXS, 4TNP, 4TNQ, 4TNR, 4TNX, 4TNY, 4TNZ, 4TO0, 4TO1, 4TO2, 4TO3, 4TO4, 4TO5, 4TO6, 4ZWE, 4ZWG, 5AO4, 5AO1, 5AO0, 5AO2, 5AO3
Dynodwyr
Cyfenwau	SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, hSAMHD1
Dynodwyr allanol	OMIM: 606754 HomoloGene: 9160 GeneCards: SAMHD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • catalytic activity • dGTP binding • RNA binding • nucleic acid binding • dGTPase activity • hydrolase activity • ribonuclease activity • triphosphoric monoester hydrolase activity • identical protein binding • nucleotide binding • single-stranded DNA binding • GTP binding Cydrannau o'r gell • Cellbilen • intracellular anatomical structure • nucleoplasm • cnewyllyn cell • Cromosom • site of double-strand break • tetraspanin-enriched microdomain Prosesau biolegol • regulation of innate immune response • immune system process • dATP catabolic process • dGTP catabolic process • defense response to virus • type I interferon signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • metabolaeth • innate immune response • protein homotetramerization • RNA phosphodiester bond hydrolysis • deoxyribonucleotide catabolic process • double-strand break repair via homologous recombination • DNA replication • GO:0100026 DNA repair • cellular response to DNA damage stimulus • somatic hypermutation of immunoglobulin genes • negative regulation of type I interferon-mediated signaling pathway • DNA strand resection involved in replication fork processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25939	n/a
Ensembl	ENSG00000101347	n/a
UniProt	Q9Y3Z3	n/a
RefSeq (mRNA)	NM_015474 NM_001363729 NM_001363733	n/a
RefSeq (protein)	NP_056289 NP_001350658 NP_001350662	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SAMHD1 yw SAMHD1 a elwir hefyd yn SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SAMHD1.

• DCIP
• CHBL2
• HDDC1
• MOP-5
• SBBI88

Llyfryddiaeth

• "Substrates and Inhibitors of SAMHD1. ". PLoS One. 2017. PMID 28046007.
• "Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells. ". Cell Cycle. 2017. PMID 27929746.
• "With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. ". Exp Hematol. 2017. PMID 28502830.
• "SAMHD1 is active in cycling cells permissive to HIV-1 infection. ". Antiviral Res. 2017. PMID 28359840.
• "Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations.". Proteins. 2017. PMID 28321930.