S100A8

S100A8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Dynodwyr
Cyfenwau	S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
Dynodwyr allanol	OMIM: 123885 HomoloGene: 2225 GeneCards: S100A8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • Toll-like receptor 4 binding • RAGE receptor binding • microtubule binding • GO:0001948, GO:0016582 protein binding • calcium ion binding • arachidonic acid binding • zinc ion binding • metal ion binding Cydrannau o'r gell • cnewyllyn cell • Cytosgerbwd • cytosol • extracellular exosome • bilen • Cellbilen • cytoplasm • extracellular space • secretory granule lumen • intermediate filament cytoskeleton • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • regulation of inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • immune system process • positive regulation of inflammatory response • neutrophil chemotaxis • positive regulation of intrinsic apoptotic signaling pathway • defense response to fungus • response to ethanol • chemokine production • response to zinc ion • acute inflammatory response • defense response to bacterium • leukocyte migration involved in inflammatory response • peptidyl-cysteine S-nitrosylation • sequestering of zinc ion • neutrophil aggregation • response to lipopolysaccharide • chemotaxis • positive regulation of peptide secretion • chronic inflammatory response • astrocyte development • wound healing • GO:0097285 apoptotic process • positive regulation of cell growth • autophagy • inflammatory response • regulation of cytoskeleton organization • GO:0032617 cytokine production • positive regulation of NF-kappaB transcription factor activity • innate immune response • toll-like receptor signaling pathway • antimicrobial humoral response • neutrophil degranulation • autocrine signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6279	n/a
Ensembl	ENSG00000143546	n/a
UniProt	P05109	n/a
RefSeq (mRNA)	NM_002964 NM_001319196 NM_001319197 NM_001319198 NM_001319201	n/a
RefSeq (protein)	NP_001306125 NP_001306126 NP_001306127 NP_001306130 NP_002955	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn S100A8 yw S100A8 a elwir hefyd yn S100 calcium binding protein A8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn S100A8.

• P8
• MIF
• NIF
• CAGA
• CFAG
• CGLA
• L1Ag
• MRP8
• CP-10
• MA387
• 60B8AG

Llyfryddiaeth

• "S100A8 is a novel therapeutic target for anaplastic thyroid carcinoma. ". J Clin Endocrinol Metab. 2015. PMID 25423568.
• "Association of increased S100A8 serum protein with early pregnancy loss. ". Am J Reprod Immunol. 2015. PMID 25252120.
• "Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus. ". Acta Derm Venereol. 2016. PMID 26632637.
• "Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4(+)CD25(+)Foxp3 regulatory T cell generation. ". Malar J. 2015. PMID 26438270.
• "Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behçet's disease and its association with disease activity and quality of life.". Scand J Clin Lab Invest. 2015. PMID 25471894.