RUVBL1

RUVBL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C9O, 2XSZ
Dynodwyr
Cyfenwau	RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1
Dynodwyr allanol	OMIM: 603449 HomoloGene: 37839 GeneCards: RUVBL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0043141 5'-3' DNA helicase activity • GO:0008026 helicase activity • GO:0004003 DNA helicase activity • ATPase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • ATP binding • cadherin binding • TFIID-class transcription factor complex binding • ADP binding • ATPase binding Cydrannau o'r gell • bilen • nuclear matrix • NuA4 histone acetyltransferase complex • nucleoplasm • microtubule organizing center • MLL1 complex • extracellular exosome • Cytosgerbwd • cnewyllyn cell • Swr1 complex • R2TP complex • cytoplasm • cytosol • Ino80 complex Prosesau biolegol • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • positive regulation of protein targeting to mitochondrion • histone H2A acetylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0061641 CENP-A containing chromatin assembly • transcription, DNA-templated • cellular response to DNA damage stimulus • Cellraniad • regulation of autophagy of mitochondrion • spermatogenesis • positive regulation of telomerase RNA localization to Cajal body • histone H4 acetylation • cell cycle • regulation of growth • beta-catenin-TCF complex assembly • DNA duplex unwinding • protein deubiquitination • GO:0100026 DNA repair • box C/D snoRNP assembly • chromatin remodeling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8607	n/a
Ensembl	ENSG00000175792 ENSG00000284901	n/a
UniProt	Q9Y265	n/a
RefSeq (mRNA)	NM_003707 NM_001319084 NM_001319086	n/a
RefSeq (protein)	NP_001306013 NP_001306015 NP_003698	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUVBL1 yw RUVBL1 a elwir hefyd yn RuvB-like helicase a RuvB like AAA ATPase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUVBL1.

• RVB1
• TIH1
• ECP54
• TIP49
• ECP-54
• INO80H
• NMP238
• PONTIN
• TIP49A
• NMP*238
• Pontin52

Llyfryddiaeth

• "RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion. ". Int J Oncol. 2014. PMID 24728183.
• "Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma. ". Oncol Rep. 2012. PMID 22895545.
• "Chromosome Missegregation Associated with RUVBL1 Deficiency. ". PLoS One. 2015. PMID 26201077.
• "Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. ". Cell Death Differ. 2015. PMID 25857266.
• "Cytoplasmic expression of pontin in renal cell carcinoma correlates with tumor invasion, metastasis and patients' survival.". PLoS One. 2015. PMID 25751257.