RUNX2

RUNX2
Dynodwyr
Cyfenwau	RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2, Runx2 mRNA, RUNX family transcription factor 2
Dynodwyr allanol	OMIM: 600211 HomoloGene: 68389 GeneCards: RUNX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • bHLH transcription factor binding • GO:0001948, GO:0016582 protein binding • ATP binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • transcription regulator complex • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • skeletal system development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of smoothened signaling pathway • chondrocyte differentiation • ossification • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • regulation of fibroblast growth factor receptor signaling pathway • skeletal system morphogenesis • chondrocyte development • cellular response to BMP stimulus • endochondral ossification • regulation of odontogenesis of dentin-containing tooth • cell maturation • BMP signaling pathway • stem cell differentiation • transcription, DNA-templated • odontogenesis of dentin-containing tooth • T cell differentiation • GO:1901313 positive regulation of gene expression • regulation of osteoblast differentiation • positive regulation of chondrocyte differentiation • osteoblast differentiation • neuron differentiation • positive regulation of cell population proliferation • regulation of cell differentiation • osteoblast development • embryonic cranial skeleton morphogenesis • regulation of ossification • embryonic forelimb morphogenesis • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • osteoblast fate commitment • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • positive regulation of osteoblast differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cell differentiation • hemopoiesis • regulation of gene expression Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	860	n/a
Ensembl	ENSG00000124813	n/a
UniProt	Q13950	n/a
RefSeq (mRNA)	NM_001015051 NM_001024630 NM_001278478 NM_004348 NM_001369405	n/a
RefSeq (protein)	NP_001015051 NP_001019801 NP_001265407 NP_001356334	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX2 yw RUNX2 a elwir hefyd yn Runt related transcription factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX2.

• CCD
• AML3
• CCD1
• CLCD
• OSF2
• CBFA1
• OSF-2
• PEA2aA
• PEBP2aA
• CBF-alpha-1

Llyfryddiaeth

• "Analysis of novel RUNX2 mutations in Chinese patients with cleidocranial dysplasia. ". PLoS One. 2017. PMID 28738062.
• "A novel RUNX2 mutation in exon 8, G462X, in a patient with Cleidocranial Dysplasia. ". J Cell Biochem. 2018. PMID 28703881.
• "Functional analysis of novel RUNX2 mutations in cleidocranial dysplasia. ". Mutagenesis. 2017. PMID 28505335.
• "Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types. ". J Cell Biochem. 2017. PMID 28370561.
• "The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.". J Cell Physiol. 2018. PMID 28345763.