RPS6KB1

RPS6KB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3A60, 3A61, 3A62, 3WE4, 3WF5, 3WF6, 3WF7, 3WF8, 3WF9, 4L3J, 4L3L, 4L42, 4L43, 4L44, 4L45, 4L46, 4RLO, 4RLP
Dynodwyr
Cyfenwau	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, P70-S6 Kinase 1, ribosomal protein S6 kinase B1, p70S6K, p70S6 kinase
Dynodwyr allanol	OMIM: 608938 HomoloGene: 81703 GeneCards: RPS6KB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • peptide binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein serine/threonine/tyrosine kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • ribosomal protein S6 kinase activity • PDZ domain binding • protein phosphatase 2A binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • synapse • nucleoplasm • cell surface • mitochondrial outer membrane • cell junction • mitocondria • perinuclear region of cytoplasm • neuron projection • cnewyllyn cell Prosesau biolegol • germ cell development • response to amino acid • response to glucagon • GO:1904578 response to organic cyclic compound • protein kinase B signaling • response to nutrient • phosphorylation • regulation of glucose import • response to testosterone • negative regulation of extrinsic apoptotic signaling pathway • cellular response to growth factor stimulus • skeletal muscle contraction • response to mechanical stimulus • GO:0010260 heneiddio • response to leucine • GO:1904579 cellular response to organic cyclic compound • positive regulation of mitotic cell cycle • negative regulation of apoptotic process • response to heat • response to glucocorticoid • response to glucose • response to peptide hormone • behavioral fear response • positive regulation of translation • response to organic substance • positive regulation of smooth muscle cell migration • response to tumor necrosis factor • response to insulin • response to lipopolysaccharide • GO:1903105 negative regulation of insulin receptor signaling pathway • cellular response to hormone stimulus • long-term memory • response to wounding • response to organonitrogen compound • response to electrical stimulus involved in regulation of muscle adaptation • skeletal muscle atrophy • cell cycle • response to ethanol • positive regulation of translational initiation • cell migration • response to toxic substance • positive regulation of skeletal muscle tissue growth • regulation of translation • phosphatidylinositol-mediated signaling • GO:0072468 signal transduction • positive regulation of smooth muscle cell proliferation • GO:0097285 apoptotic process • protein phosphorylation • cellular response to dexamethasone stimulus • cellular response to insulin stimulus • G1/S transition of mitotic cell cycle • GO:0035404 peptidyl-serine phosphorylation • TOR signaling • cellular response to interferon-gamma • long-chain fatty acid import into cell • GO:0007243 intracellular signal transduction • response to nutrient levels Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6198	n/a
Ensembl	ENSG00000108443	n/a
UniProt	P23443	n/a
RefSeq (mRNA)	NM_001272042 NM_001272043 NM_001272044 NM_001272060 NM_003161	n/a
RefSeq (protein)	NP_001258971 NP_001258972 NP_001258973 NP_001258989 NP_003152 NP_001356598 NP_001356599 NP_001356600 NP_001356601 NP_001356602 NP_001356603 NP_001356604 NP_001356605 NP_001356606 NP_001356607 NP_001356608	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RPS6KB1 yw RPS6KB1 a elwir hefyd yn Ribosomal protein S6 kinase B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RPS6KB1.

• S6K
• PS6K
• S6K1
• STK14A
• p70-S6K
• p70*S6KA
• p70-alpha
• S6K-beta-1
• p70(S6K)-alpha

Llyfryddiaeth

• "Involvement of S6K1 in mitochondria function and structure in HeLa cells. ". Cell Signal. 2016. PMID 27634387.
• "Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma. ". J Immunol Res. 2016. PMID 27595116.
• "Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients. ". PLoS One. 2017. PMID 28792981.
• "Association of ribosomal protein S6 kinase 1 with cellular radiosensitivity of non-small lung cancer. ". Int J Radiat Biol. 2017. PMID 28276898.
• "Trastuzumab stimulation of ribosomal protein S6 kinase 1 (S6K1) predicts de novo trastuzumab resistance.". Biochem Biophys Res Commun. 2017. PMID 27993682.