RPS6KA1

RPS6KA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WNT, 2Z7Q, 2Z7R, 2Z7S, 3RNY, 4H3P, 4NIF, 5CSJ, 5CSF, 5CSN, 5CSI
Dynodwyr
Cyfenwau	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, ribosomal protein S6 kinase A1, MAPKAPK1
Dynodwyr allanol	OMIM: 601684 HomoloGene: 55703 GeneCards: RPS6KA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • ATP binding • magnesium ion binding • kinase activity • ribosomal protein S6 kinase activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of translation in response to stress • GO:0007243 intracellular signal transduction • phosphorylation • negative regulation of apoptotic process • protein phosphorylation • positive regulation of cell growth • hepatocyte proliferation • positive regulation of cell differentiation • positive regulation of hepatic stellate cell activation • cell cycle • regulation of DNA-templated transcription in response to stress • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6195	n/a
Ensembl	ENSG00000117676 ENSG00000281877	n/a
UniProt	Q15418	n/a
RefSeq (mRNA)	NM_001006665 NM_002953 NM_001330441	n/a
RefSeq (protein)	NP_001006666 NP_001317370 NP_002944	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RPS6KA1 yw RPS6KA1 a elwir hefyd yn Ribosomal protein S6 kinase A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RPS6KA1.

• RSK
• HU-1
• RSK1
• p90Rsk
• MAPKAPK1A

Llyfryddiaeth

• "Protein preparation, crystallization and preliminary X-ray analysis of the C-terminal domain of human RSK1 serine/threonine protein kinase. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID 18084084.
• "Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. ". Protein Sci. 2007. PMID 17965187.
• "RSK1 activation promotes invasion in nodular melanoma. ". Am J Pathol. 2015. PMID 25579842.
• "p90 ribosomal S6 kinase 1 (RSK1) isoenzyme specifically regulates cytokinesis progression. ". Cell Signal. 2014. PMID 24269382.
• "Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.". Acta Crystallogr D Biol Crystallogr. 2012. PMID 22683790.