RORA

RORA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N83, 1S0X, 4S15
Dynodwyr
Cyfenwau	RORA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, RAR related orphan receptor A, IDDECA
Dynodwyr allanol	OMIM: 600825 HomoloGene: 56594 GeneCards: RORA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • beta-catenin binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • ligand-activated transcription factor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • transcription factor binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • core promoter sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • transcription coactivator binding • transcription corepressor binding • oxysterol binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell Prosesau biolegol • negative regulation of fat cell differentiation • nitric oxide biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • cGMP metabolic process • proses rythmig • cellular response to sterol • cellular response to tumor necrosis factor • cerebellar Purkinje cell differentiation • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • transcription, DNA-templated • cerebellar granule cell precursor proliferation • regulation of steroid metabolic process • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of smoothened signaling pathway • muscle cell differentiation • intracellular receptor signaling pathway • regulation of glucose metabolic process • regulation of circadian rhythm • angiogenesis • cellular response to interleukin-1 • xenobiotic metabolic process • positive regulation of circadian rhythm • positive regulation of vascular endothelial growth factor production • T-helper 17 cell differentiation • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • cellular response to hypoxia • triglyceride homeostasis • regulation of macrophage activation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • Rhythm circadaidd • cytokine-mediated signaling pathway • cholesterol homeostasis • multicellular organism development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6095	n/a
Ensembl	ENSG00000069667	n/a
UniProt	P35398	n/a
RefSeq (mRNA)	NM_002943 NM_134260 NM_134261 NM_134262	n/a
RefSeq (protein)	NP_002934 NP_599022 NP_599023 NP_599024	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RORA yw RORA a elwir hefyd yn RAR related orphan receptor A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RORA.

• ROR1
• ROR2
• ROR3
• RZRA
• NR1F1
• RZR-ALPHA

Llyfryddiaeth

• "Support for the association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China. ". Asian J Psychiatr. 2017. PMID 28262136.
• "Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. ". Exp Cell Res. 2017. PMID 28238834.
• "RAR-related orphan receptor A (RORA): A new susceptibility gene for multiple sclerosis. ". J Neurol Sci. 2016. PMID 27653902.
• "Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. ". EBioMedicine. 2016. PMID 27568222.
• "Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats.". Epilepsy Behav. 2016. PMID 26731717.