ROBO2

ROBO2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UEM, 1UJT, 2EDJ
Dynodwyr
Cyfenwau	ROBO2, SAX3, roundabout guidance receptor 2
Dynodwyr allanol	OMIM: 602431 HomoloGene: 43188 GeneCards: ROBO2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • axon guidance receptor activity Cydrannau o'r gell • integral component of membrane • bilen • cell surface • axolemma • extracellular exosome • Cellbilen Prosesau biolegol • cell differentiation • ureteric bud development • kidney development • negative regulation of synapse assembly • Roundabout signaling pathway • positive regulation of axonogenesis • nervous system development • multicellular organism development • chemotaxis • central nervous system development • cellular response to hormone stimulus • olfactory bulb interneuron development • apoptotic process involved in luteolysis • negative regulation of negative chemotaxis • axon midline choice point recognition • metanephros development • homophilic cell adhesion via plasma membrane adhesion molecules • retinal ganglion cell axon guidance • brain development • spinal cord development • axon guidance • outflow tract septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion formation • positive regulation of Notch signaling pathway involved in heart induction • aorta development • ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6092	n/a
Ensembl	ENSG00000185008	n/a
UniProt	Q9HCK4	n/a
RefSeq (mRNA)	NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942 NM_001378190 NM_001378191 NM_001378192 NM_001378193 NM_001378194 NM_001378195 NM_001378196 NM_001378197 NM_001378198 NM_001378199 NM_001378200 NM_001378201 NM_001378202 NM_001378203 NM_001394212 NM_001394213 NM_001394214 NM_001395656 NM_001395657	n/a
RefSeq (protein)	NP_001122401 NP_001276968 NP_001276969 NP_001276994 NP_002933 NP_001365119 NP_001365120 NP_001365121 NP_001365122 NP_001365123 NP_001365124 NP_001365125 NP_001365126 NP_001365127 NP_001365128 NP_001365129 NP_001365130 NP_001365131 NP_001365132	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ROBO2 yw ROBO2 a elwir hefyd yn Roundabout homolog 2 a Roundabout guidance receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ROBO2.

• SAX3

Llyfryddiaeth

• "Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children. ". Psychiatr Genet. 2013. PMID 23982283.
• "Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux. ". Kidney Int. 2013. PMID 23536131.
• "Robo Ig4 Is a Dimerization Domain. ". J Mol Biol. 2017. PMID 29017837.
• "ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia. ". Pediatr Res. 2016. PMID 27002985.
• "Down-regulation of ROBO2 expression in prostate cancers.". Pathol Oncol Res. 2014. PMID 24272677.