RNF41

RNF41
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FZP, 2GWF
Dynodwyr
Cyfenwau	RNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
Dynodwyr allanol	HomoloGene: 4226 GeneCards: RNF41
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interleukin-3 receptor binding • erythropoietin receptor binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • transferase activity • GO:0050372 ubiquitin-protein transferase activity • protein domain specific binding • receptor tyrosine kinase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • cytosol • perinuclear region of cytoplasm • endoplasmic reticulum tubular network Prosesau biolegol • regulation of MAPK cascade • extrinsic apoptotic signaling pathway • positive regulation of DNA-binding transcription factor activity • protein polyubiquitination • GO:1904489 regulation of reactive oxygen species metabolic process • autophagy • negative regulation of cell migration • regulation of lymphocyte differentiation • positive regulation of reactive oxygen species metabolic process • protein ubiquitination • regulation of protein kinase B signaling • regulation of gene expression • proteasomal protein catabolic process • regulation of myeloid cell differentiation • regulation of establishment of cell polarity • negative regulation of cell population proliferation • protein autoubiquitination • GO:0097285 apoptotic process • negative regulation of mitophagy • GO:1903364 positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10193	n/a
Ensembl	ENSG00000181852	n/a
UniProt	Q9H4P4	n/a
RefSeq (mRNA)	NM_001242826 NM_005785 NM_194358 NM_194359	n/a
RefSeq (protein)	NP_001229755 NP_005776 NP_919339 NP_919340	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF41 yw RNF41 a elwir hefyd yn E3 ubiquitin-protein ligase NRDP1 a Ring finger protein 41 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNF41.

• FLRF
• NRDP1
• SBBI03

Llyfryddiaeth

• "Nrdp1 expression to predict clinical outcome and efficacy of adjuvant anthracyclines-based chemotherapy in breast cancer: A retrospective study. ". Cancer Biomark. 2015. PMID 25519010.
• "Lower expression of Nrdp1 in human glioma contributes tumor progression by reducing apoptosis. ". IUBMB Life. 2014. PMID 25355637.
• "Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population. ". Genet Mol Res. 2016. PMID 27323192.
• "The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1. ". Carcinogenesis. 2015. PMID 26464195.
• "Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1).". J Neurooncol. 2015. PMID 26088461.