RNF146

RNF146
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D8T, 3V3L
Dynodwyr
Cyfenwau	RNF146, dJ351K20.1, ring finger protein 146
Dynodwyr allanol	OMIM: 612137 HomoloGene: 12227 GeneCards: RNF146
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • GO:0001948, GO:0016582 protein binding • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • poly-ADP-D-ribose binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • transferase activity Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • nucleoplasm • Cellbilen Prosesau biolegol • positive regulation of canonical Wnt signaling pathway • protein K48-linked ubiquitination • protein ubiquitination • protein autoubiquitination • ubiquitin-dependent protein catabolic process • Wnt signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	81847	n/a
Ensembl	ENSG00000118518	n/a
UniProt	Q9NTX7	n/a
RefSeq (mRNA)	NM_001242844 NM_001242845 NM_001242846 NM_001242847 NM_001242848 NM_001242849 NM_001242850 NM_001242851 NM_001242852 NM_030963	n/a
RefSeq (protein)	NP_001229773 NP_001229774 NP_001229775 NP_001229776 NP_001229777 NP_001229778 NP_001229779 NP_001229780 NP_001229781 NP_112225	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF146 yw RNF146 a elwir hefyd yn Ring finger protein 146 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q22.33.

Llyfryddiaeth

• "The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women. ". Fam Cancer. 2009. PMID 19517271.
• "Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. ". Proc Natl Acad Sci U S A. 2008. PMID 18326623.
• "Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway. ". PLoS One. 2014. PMID 24454854.
• "Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase. ". Cell Adh Migr. 2011. PMID 22274711.
• "Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.". Genes Dev. 2012. PMID 22267412.