RNASEL

RNASEL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WDY, 4G8K, 4G8L, 4OAU, 4OAV
Dynodwyr
Cyfenwau	RNASEL, PRCA1, RNS4, ribonuclease L
Dynodwyr allanol	OMIM: 180435 HomoloGene: 8040 GeneCards: RNASEL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein kinase activity • rRNA binding • metal ion binding • endoribonuclease activity • ribonuclease activity • GO:0001948, GO:0016582 protein binding • RNA binding • nuclease activity • ribonucleoprotein complex binding • endonuclease activity • hydrolase activity • ATP binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear matrix • mitochondrial matrix • mitocondria • cydran cellog Prosesau biolegol • regulation of mRNA stability • nucleic acid phosphodiester bond hydrolysis • mRNA processing • protein phosphorylation • negative regulation of viral genome replication • RNA phosphodiester bond hydrolysis • defense response to virus • type I interferon signaling pathway • rRNA processing • fat cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • RNA phosphodiester bond hydrolysis, endonucleolytic • regulation of type I interferon-mediated signaling pathway • positive regulation of glucose import Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6041	n/a
Ensembl	ENSG00000135828	n/a
UniProt	Q05823	n/a
RefSeq (mRNA)	NM_021133	n/a
RefSeq (protein)	NP_066956	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNASEL yw RNASEL a elwir hefyd yn Ribonuclease L (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNASEL.

• RNS4
• PRCA1

Llyfryddiaeth

• "Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery. ". RNA. 2017. PMID 28808124.
• "Human serum RNase-L level is inversely associated with metabolic syndrome and age. ". Cardiovasc Diabetol. 2017. PMID 28399925.
• "RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells. ". Int J Mol Sci. 2017. PMID 28257035.
• "The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response. ". Int J Mol Sci. 2016. PMID 26760998.
• "Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.". Proc Natl Acad Sci U S A. 2015. PMID 26668391.