RNASE1

RNASE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DZA, 1E21, 1H8X, 1Z7X, 2E0J, 2E0L, 2E0M, 2E0O, 2K11, 2Q4G, 3F8G, 4KXH
Dynodwyr
Cyfenwau	RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
Dynodwyr allanol	OMIM: 180440 HomoloGene: 7919 GeneCards: RNASE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nuclease activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • ribonuclease A activity • nucleic acid binding • endonuclease activity • ribonuclease activity • lyase activity Cydrannau o'r gell • extracellular region • extracellular exosome Prosesau biolegol • RNA phosphodiester bond hydrolysis, endonucleolytic • defense response to virus • RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6035	n/a
Ensembl	ENSG00000129538	n/a
UniProt	P07998	n/a
RefSeq (mRNA)	NM_198235 NM_002933 NM_198232 NM_198234	n/a
RefSeq (protein)	NP_002924 NP_937875 NP_937877 NP_937878	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNASE1 yw RNASE1 a elwir hefyd yn Ribonuclease A family member 1, pancreatic (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNASE1.

• RAC1
• RIB1
• RNS1

Llyfryddiaeth

• "Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease. ". PLoS One. 2011. PMID 21408145.
• "The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity. ". Invest New Drugs. 2011. PMID 20352290.
• "Increased N-glycosylation of Asn⁸⁸ in serum pancreatic ribonuclease 1 is a novel diagnostic marker for pancreatic cancer. ". Sci Rep. 2014. PMID 25336120.
• "Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase. ". Acta Crystallogr D Biol Crystallogr. 2013. PMID 24100329.
• "Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.". Biophys J. 2011. PMID 21767499.