RMI1

RMI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3MXN, 3NBH, 3NBI, 4CGY, 4CHT, 4DAY
Dynodwyr
Cyfenwau	RMI1, BLAP75, C9orf76, FAAP75, RecQ mediated genome instability 1
Dynodwyr allanol	OMIM: 610404 HomoloGene: 41601 GeneCards: RMI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • nuclear body • RecQ family helicase-topoisomerase III complex Prosesau biolegol • DNA replication • response to dietary excess • reduction of food intake in response to dietary excess • response to glucose • multicellular organism growth • glucose homeostasis • resolution of meiotic recombination intermediates • double-strand break repair via homologous recombination • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	80010	n/a
Ensembl	ENSG00000178966	n/a
UniProt	Q9H9A7	n/a
RefSeq (mRNA)	NM_024945 NM_001358291 NM_001358292 NM_001358293 NM_001358294	n/a
RefSeq (protein)	NP_079221 NP_001345220 NP_001345221 NP_001345222 NP_001345223	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RMI1 yw RMI1 a elwir hefyd yn RecQ mediated genome instability 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RMI1.

• BLAP75
• FAAP75
• C9orf76

Llyfryddiaeth

• "RMI1 promotes DNA replication fork progression and recovery from replication fork stress. ". Mol Cell Biol. 2012. PMID 22645306.
• "Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma. ". Cancer Lett. 2007. PMID 17900800.
• "Knockdown of RMI1 impairs DNA repair under DNA replication stress. ". Biochem Biophys Res Commun. 2017. PMID 29042194.
• "Structural Motifs Critical for In Vivo Function and Stability of the RecQ-Mediated Genome Instability Protein Rmi1. ". PLoS One. 2015. PMID 26717309.
• "Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.". Int J Mol Sci. 2015. PMID 26556339.