RHEB

RHEB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XTQ, 1XTR, 1XTS, 3SEA, 3T5G
Dynodwyr
Cyfenwau	RHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding
Dynodwyr allanol	OMIM: 601293 HomoloGene: 123916 GeneCards: RHEB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • metal ion binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • magnesium ion binding • GO:0006184 GTPase activity • GTP binding • GDP binding Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • endoplasmic reticulum membrane • bilen • Golgi membrane • lysosomal membrane • Reticwlwm endoplasmig • spliceosomal complex • extracellular exosome • endomembrane system • GO:0097483, GO:0097481 postsynaptic density • Cellbilen Prosesau biolegol • positive regulation of oligodendrocyte differentiation • regulation of TOR signaling • regulation of type B pancreatic cell development • positive regulation of TOR signaling • GO:0072468 signal transduction • regulation of macroautophagy • negative regulation of cold-induced thermogenesis • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6009	n/a
Ensembl	ENSG00000106615	n/a
UniProt	Q15382	n/a
RefSeq (mRNA)	NM_005614	n/a
RefSeq (protein)	NP_005605	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHEB yw RHEB a elwir hefyd yn Ras homolog, mTORC1 binding (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHEB.

• RHEB2

Llyfryddiaeth

• "Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells. ". Cancer Lett. 2010. PMID 20554106.
• "Regulation of androgen receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate cancer cell proliferation. ". Prostate. 2010. PMID 20127734.
• "Rheb and Rags come together at the lysosome to activate mTORC1. ". Biochem Soc Trans. 2013. PMID 23863162.
• "Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc. ". J Am Chem Soc. 2013. PMID 23409921.
• "Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.". J Biol Chem. 2010. PMID 20685651.