REV3L

REV3L
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Dynodwyr
Cyfenwau	REV3L, POLZ, REV3, REV3 like, DNA directed polymerase zeta catalytic subunit
Dynodwyr allanol	OMIM: 602776 HomoloGene: 48147 GeneCards: REV3L
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • DNA binding • 4 iron, 4 sulfur cluster binding • nucleotidyltransferase activity • iron-sulfur cluster binding • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • DNA-directed DNA polymerase activity • 3'-5' exonuclease activity Cydrannau o'r gell • nucleoplasm • nucleolus • cnewyllyn cell • zeta DNA polymerase complex Prosesau biolegol • DNA-dependent DNA replication • error-prone translesion synthesis • cellular response to DNA damage stimulus • DNA replication • GO:0100026 DNA repair • translesion synthesis • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5980	n/a
Ensembl	ENSG00000009413	n/a
UniProt	O60673	n/a
RefSeq (mRNA)	NM_001286431 NM_001286432 NM_002912 NM_001372078	n/a
RefSeq (protein)	NP_001273360 NP_001273361 NP_002903 NP_001359007	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn REV3L yw REV3L a elwir hefyd yn REV3 like, DNA directed polymerase zeta catalytic subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn REV3L.

• POLZ
• REV3

Llyfryddiaeth

• "Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome. ". PLoS One. 2015. PMID 26462070.
• "REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells. ". Oncol Rep. 2015. PMID 26165320.
• "Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses. ". DNA Repair (Amst). 2016. PMID 27338670.
• "Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. ". Sci Rep. 2016. PMID 26790612.
• "REV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.". Oncol Rep. 2016. PMID 26752104.