REV1

REV1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EBW, 2LSI, 2LSK, 2LSY, 3GQC, 3VU7, 4BA9, 4EXT, 4GK0, 4GK5, 2N1G
Dynodwyr
Cyfenwau	REV1, REV1L, AIBP80, DNA directed polymerase, REV1 DNA directed polymerase
Dynodwyr allanol	OMIM: 606134 HomoloGene: 32309 GeneCards: REV1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • damaged DNA binding • DNA binding • nucleotidyltransferase activity • GO:0001948, GO:0016582 protein binding • metal ion binding • deoxycytidyl transferase activity Cydrannau o'r gell • cnewyllyn cell • nucleoplasm Prosesau biolegol • DNA replication • translesion synthesis • DNA biosynthetic process • response to UV • error-prone translesion synthesis • cellular response to DNA damage stimulus • GO:0100026 DNA repair Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51455	n/a
Ensembl	ENSG00000135945	n/a
UniProt	Q9UBZ9	n/a
RefSeq (mRNA)	NM_001037872 NM_016316 NM_001321454 NM_001321455 NM_001321458 NM_001321459 NM_001321460	n/a
RefSeq (protein)	NP_001032961 NP_001308383 NP_001308384 NP_001308387 NP_001308388 NP_001308389 NP_057400	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn REV1 yw REV1 a elwir hefyd yn DNA repair protein REV1 a REV1, DNA directed polymerase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn REV1.

• REV1L
• AIBP80

Llyfryddiaeth

• "Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. ". J Mol Biol. 2010. PMID 20888339.
• "Specific amino acid residues are involved in substrate discrimination and template binding of human REV1 protein. ". Biochem Biophys Res Commun. 2010. PMID 20059978.
• "Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. ". Chem Res Toxicol. 2016. PMID 26914252.
• "Human Rev1 polymerase disrupts G-quadruplex DNA. ". Nucleic Acids Res. 2014. PMID 24366879.
• "Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain.". J Mol Cell Biol. 2013. PMID 23220741.