RELB

RELB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZK9, 1ZKA, 2V2T, 3DO7, 3JSS, 3JUZ, 3JV0, 3JV4, 3JV6, 4JGM, 4JHB
Dynodwyr
Cyfenwau	RELB, I-REL, IREL, REL-B, RELB proto-oncogene, NF-kB subunit, IMD53
Dynodwyr allanol	OMIM: 604758 HomoloGene: 4747 GeneCards: RELB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • I-kappaB/NF-kappaB complex • nucleoplasm • microtubule organizing center • Cytosgerbwd • cnewyllyn cell • cytoplasm • cytosol • centrosome • GO:0009327 protein-containing complex • transcription repressor complex Prosesau biolegol • response to cytokine • antigen processing and presentation • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • myeloid dendritic cell differentiation • stimulatory C-type lectin receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • T-helper 1 cell differentiation • negative regulation of interferon-beta production • circadian regulation of gene expression • transcription, DNA-templated • cellular response to osmotic stress • GO:1901313 positive regulation of gene expression • NIK/NF-kappaB signaling • T-helper 1 type immune response • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • I-kappaB kinase/NF-kappaB signaling • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • innate immune response • lymphocyte differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5971	n/a
Ensembl	ENSG00000104856	n/a
UniProt	Q01201	n/a
RefSeq (mRNA)	NM_006509	n/a
RefSeq (protein)	NP_006500	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RELB yw RELB a elwir hefyd yn Transcription factor RelB a RELB proto-oncogene, NF-kB subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RELB.

• IREL
• I-REL
• IMD53
• REL-B

Llyfryddiaeth

• "Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism. ". Biochem Biophys Res Commun. 2015. PMID 25511695.
• "Alterations in the expression of the NF-κB family member RelB as a novel marker of cardiovascular outcomes during acute exacerbations of chronic obstructive pulmonary disease. ". PLoS One. 2014. PMID 25409035.
• "RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?". Sci Rep. 2015. PMID 26463648.
• "The effects of RelB deficiency on lymphocyte development and function. ". J Autoimmun. 2015. PMID 26385063.
• "RELB Alters Proliferation of Human Pluripotent Stem Cells via IMP3- and LIN28-Mediated Modulation of the Expression of IGF2 and Other Cell-Cycle Regulators.". Stem Cells Dev. 2015. PMID 25794352.