RDX

RDX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
Dynodwyr
Cyfenwau	RDX, DFNB24, radixin
Dynodwyr allanol	OMIM: 179410 HomoloGene: 37707 GeneCards: RDX
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • protein domain specific binding • ATPase binding • protein kinase A binding • cytoskeletal protein binding • GO:0001948, GO:0016582 protein binding • actin binding • RNA binding • cadherin binding Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • filopodium • ruffle • myelin sheath • Cellbilen • apical part of cell • stereocilium • microvillus • apical plasma membrane • cortical actin cytoskeleton • cleavage furrow • extracellular exosome • Cytosgerbwd • cyrion cell • lamellipodium • midbody • T-tubule • cell tip • extracellular space • cell projection Prosesau biolegol • regulation of cell size • establishment of endothelial barrier • microvillus assembly • regulation of organelle assembly • establishment of protein localization • positive regulation of cell migration • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of homotypic cell-cell adhesion • regulation of actin filament bundle assembly • GO:1901313 positive regulation of gene expression • GO:0034259 negative regulation of GTPase activity • negative regulation of adherens junction organization • apical protein localization • actin filament capping • cellular response to thyroid hormone stimulus • regulation of cell shape • protein kinase A signaling • regulation of ruffle assembly • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • negative regulation of cell size • regulation of Rap protein signal transduction • cellular response to platelet-derived growth factor stimulus • barbed-end actin filament capping • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5962	n/a
Ensembl	ENSG00000137710	n/a
UniProt	P35241	n/a
RefSeq (mRNA)	NM_002906 NM_001260492 NM_001260493 NM_001260494 NM_001260495 NM_001260496	n/a
RefSeq (protein)	NP_001247421 NP_001247422 NP_001247423 NP_001247424 NP_001247425 NP_002897	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RDX yw RDX a elwir hefyd yn Radixin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RDX.

• DFNB24

Llyfryddiaeth

• "Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo. ". Asian Pac J Cancer Prev. 2012. PMID 22631643.
• "A novel splice site mutation in the RDX gene causes DFNB24 hearing loss in an Iranian family. ". Am J Med Genet A. 2009. PMID 19215054.
• "Radixin knockdown by RNA interference suppresses human glioblastoma cell growth in vitro and in vivo. ". Asian Pac J Cancer Prev. 2014. PMID 25520109.
• "MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer. ". Cancer Lett. 2014. PMID 24933454.
• "Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population.". Genet Mol Res. 2014. PMID 24854655.