RBPJ Dynodwyr Cyfenwau RBPJ , AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1Dynodwyr allanol OMIM: 147183 HomoloGene: 7511 GeneCards: RBPJ Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • GO:0001948, GO:0016582 protein binding • DNA strand exchange activity • chromatin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleolus • MAML1-RBP-Jkappa- ICN1 complex • transcription regulator complex • cytoplasm • cnewyllyn cell • nucleoplasm • transcription repressor complex Prosesau biolegol • artery morphogenesis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • neuron differentiation • epidermal cell fate specification • positive regulation of cell population proliferation • club cell differentiation • somatic stem cell population maintenance • endocardium development • cell fate commitment • DNA recombination • somitogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • defense response to bacterium • regulation of timing of cell differentiation • GO:0009373 regulation of transcription, DNA-templated • humoral immune response • keratinocyte differentiation • hair follicle maturation • negative regulation of cell population proliferation • pituitary gland development • negative regulation of cell differentiation • Notch signaling involved in heart development • transcription, DNA-templated • GO:1901313 positive regulation of gene expression • arterial endothelial cell fate commitment • myeloid dendritic cell differentiation • blood vessel remodeling • secondary heart field specification • regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription initiation from RNA polymerase II promoter • sebaceous gland development • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • inflammatory response to antigenic stimulus • heart development • auditory receptor cell fate commitment • B cell differentiation • regulation of gene expression • Notch signaling pathway • dorsal aorta morphogenesis • atrioventricular canal development • positive regulation of ephrin receptor signaling pathway • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • cardiac left ventricle morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • labyrinthine layer blood vessel development • blood vessel lumenization • endocardium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of ossification • positive regulation of cell proliferation involved in heart morphogenesis • positive regulation of cardiac muscle cell proliferation • angiogenesis • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • positive regulation of ERBB signaling pathway • blood vessel endothelial cell fate specification • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of transcription of Notch receptor target • positive regulation of Notch signaling pathway • hemopoiesis • aortic valve development • pulmonary valve development • ventricular septum morphogenesis • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn RBPJ yw RBPJ a elwir hefyd yn Recombination signal binding protein for immunoglobulin kappa J region a Recombining-binding protein suppressor of hairless (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RBPJ.
SUH
csl
AOS3
CBF1
KBF2
RBP-J
RBPJK
IGKJRB
RBPSUH
IGKJRB1
"CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. ". Br J Cancer . 2017. PMID 28571041 .
"Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells. ". Hum Mol Genet . 2016. PMID 26604133 .
"Inhibition of Recombining Binding Protein Suppressor of Hairless (RBPJ) Impairs the Growth of Prostate Cancer. ". Cell Physiol Biochem . 2015. PMID 26202358 .
"RBPJ inhibition impairs the growth of lung cancer. ". Tumour Biol . 2015. PMID 25589461 .
"Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines. ". PLoS Pathog . 2013. PMID 23696732 .