RBM8A

RBM8A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Dynodwyr
Cyfenwau	RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA binding motif protein 8A
Dynodwyr allanol	OMIM: 605313 HomoloGene: 3744 GeneCards: RBM8A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA binding • mRNA binding Cydrannau o'r gell • cytosol • catalytic step 2 spliceosome • exon-exon junction complex • neuronal cell body • dendrite • spliceosomal complex • cnewyllyn cell • cytoplasm • nucleoplasm • nuclear speck • U2-type catalytic step 1 spliceosome Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • GO:0033168, GO:0036404, GO:1902360 RNA processing • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • mRNA export from nucleus • mRNA 3'-end processing • regulation of translation • RNA export from nucleus • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • RNA splicing • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9939	n/a
Ensembl	ENSG00000265241	n/a
UniProt	Q9Y5S9	n/a
RefSeq (mRNA)	NM_005105	n/a
RefSeq (protein)	NP_005096	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RBM8A yw RBM8A a elwir hefyd yn RNA binding motif protein 8A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RBM8A.

• TAR
• Y14
• RBM8
• ZNRP
• RBM8B
• ZRNP1
• BOV-1A
• BOV-1B
• BOV-1C
• MDS014
• DEL1q21.1
• C1DELq21.1

Llyfryddiaeth

• "Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein. ". J Immunol. 2013. PMID 23817415.
• "Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. ". Nat Genet. 2012. PMID 22366785.
• "High expression of RBM8A predicts poor patient prognosis and promotes tumor progression in hepatocellular carcinoma. ". Oncol Rep. 2017. PMID 28259942.
• "A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement. ". J Biol Chem. 2016. PMID 26887951.
• "Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.". Exp Biol Med (Maywood). 2013. PMID 23970407.