RBCK1

RBCK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CRC, 2LGY, 4DBG
Dynodwyr
Cyfenwau	RBCK1, C20orf18, HOIL-1, HOIL1, PBMEI, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4, PGBM1, RANBP2-type and C3HC4-type zinc finger containing 1
Dynodwyr allanol	OMIM: 610924 HomoloGene: 32448 GeneCards: RBCK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • identical protein binding Cydrannau o'r gell • cytosol • LUBAC complex Prosesau biolegol • negative regulation of necroptotic process • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of extrinsic apoptotic signaling pathway • GO:0022415 viral process • I-kappaB kinase/NF-kappaB signaling • negative regulation of NF-kappaB transcription factor activity • T cell receptor signaling pathway • protein linear polyubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • protein polyubiquitination • positive regulation of NIK/NF-kappaB signaling • GO:0009373 regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10616	n/a
Ensembl	ENSG00000125826	n/a
UniProt	Q9BYM8	n/a
RefSeq (mRNA)	NM_006462 NM_031227 NM_031228 NM_031229 NM_001323956 NM_001323958 NM_001323960	n/a
RefSeq (protein)	NP_001310885 NP_001310887 NP_001310889 NP_006453 NP_112506	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RBCK1 yw RBCK1 a elwir hefyd yn HCG2019817, isoform CRA_d a RANBP2-type and C3HC4-type zinc finger containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RBCK1.

• XAP3
• XAP4
• HOIL1
• PBMEI
• PGBM1
• RBCK2
• RNF54
• HOIL-1
• ZRANB4
• C20orf18
• UBCE7IP3

Llyfryddiaeth

• "Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. ". J Exp Med. 2015. PMID 26008899.
• "Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. ". Cell Res. 2008. PMID 18711448.
• "Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1. ". Ann Neurol. 2013. PMID 23798481.
• "Cytoplasmic tethering of a RING protein RBCK1 by its splice variant lacking the RING domain. ". Biochem Biophys Res Commun. 2005. PMID 16083853.
• "The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling.". J Cell Sci. 2016. PMID 27006117.