RARB

RARB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI
Dynodwyr
Cyfenwau	RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta
Dynodwyr allanol	OMIM: 180220 HomoloGene: 68100 GeneCards: RARB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • retinoid X receptor binding • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • growth plate cartilage development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • neurogenesis • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cartilage development • multicellular organism growth • embryonic eye morphogenesis • positive regulation of programmed cell death • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • retinal pigment epithelium development • transcription, DNA-templated • outflow tract septum morphogenesis • negative regulation of chondrocyte differentiation • retinoic acid receptor signaling pathway • regulation of myelination • retina development in camera-type eye • positive regulation of neuron differentiation • positive regulation of cell population proliferation • positive regulation of apoptotic process • ventricular cardiac muscle cell differentiation • transcription initiation from RNA polymerase II promoter • bone development • embryonic digestive tract development • striatum development • GO:0072468 signal transduction • negative regulation of cell population proliferation • glandular epithelial cell development • steroid hormone mediated signaling pathway • embryonic hindlimb morphogenesis • liver development • multicellular organism development • hormone-mediated signaling pathway • cell differentiation • response to retinoic acid • response to lipid • gland development • bone morphogenesis • epithelium development • cellular response to retinoic acid Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5915	n/a
Ensembl	ENSG00000077092	n/a
UniProt	P10826 Q5QHG3	n/a
RefSeq (mRNA)	NM_000965 NM_001290216 NM_001290217 NM_001290266 NM_001290276 NM_001290277 NM_001290300 NM_016152	n/a
RefSeq (protein)	NP_000956 NP_001277145 NP_001277146 NP_001277195 NP_001277205 NP_001277206 NP_001277229 NP_057236 NP_001277146.1 NP_001277205.1 NP_057236.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RARB yw RARB a elwir hefyd yn Retinoic acid receptor beta 5 a Retinoic acid receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RARB.

• HAP
• RRB2
• NR1B2
• MCOPS12
• RARbeta1

Llyfryddiaeth

• "Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation. ". Phytother Res. 2015. PMID 25981383.
• "Association of methylation of the RAR-β gene with cigarette smoking in non-small cell lung cancer with Southern-Central Chinese population. ". Asian Pac J Cancer Prev. 2014. PMID 25605205.
• "Gain-of-Function Mutations in RARB Cause Intellectual Disability with Progressive Motor Impairment. ". Hum Mutat. 2016. PMID 27120018.
• "Promoter Methylation of the Retinoic Acid Receptor Beta2 (RARβ2) Is Associated with Increased Risk of Breast Cancer: A PRISMA Compliant Meta-Analysis. ". PLoS One. 2015. PMID 26451736.
• "Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation.". Proc Natl Acad Sci U S A. 2015. PMID 26080448.