RANGAP1

RANGAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2IY0, 3UIN, 3UIO, 3UIP, 5D2M, 2IO2, 2IO3
Dynodwyr
Cyfenwau	RANGAP1, Fug1, RANGAP, SD, Ran GTPase activating protein 1
Dynodwyr allanol	OMIM: 602362 HomoloGene: 55700 GeneCards: RANGAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • cadherin binding • RNA binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • ubiquitin protein ligase binding Cydrannau o'r gell • intracellular membrane-bounded organelle • cytoplasmic periphery of the nuclear pore complex • nuclear pore • Cromosom • dendrite • nuclear pore cytoplasmic filaments • mitotic spindle • chromosome, centromeric region • Cytosgerbwd • cnewyllyn cell • kinetochore • axon cytoplasm • cytoplasm • cytosol • aggresome • perinuclear region of cytoplasm • nuclear envelope • nucleoplasm • spindle • nuclear membrane Prosesau biolegol • cellular response to vasopressin • protein sumoylation • cellular response to peptide hormone stimulus • negative regulation of protein export from nucleus • response to axon injury • GO:0072468 signal transduction • sister chromatid cohesion • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5905	n/a
Ensembl	ENSG00000100401	n/a
UniProt	P46060	n/a
RefSeq (mRNA)	NM_001278651 NM_002883 NM_001317930	n/a
RefSeq (protein)	NP_001265580 NP_001304859 NP_002874	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RANGAP1 yw RANGAP1 a elwir hefyd yn Ran GTPase activating protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RANGAP1.

• SD
• Fug1
• RANGAP

Llyfryddiaeth

• "Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. ". Curr Biol. 2001. PMID 11231159.
• "Conserved charged residues in the leucine-rich repeat domain of the Ran GTPase activating protein are required for Ran binding and GTPase activation. ". Biochem J. 1999. PMID 10527945.
• "The RanBP2/RanGAP1*SUMO1/Ubc9 complex: a multisubunit E3 ligase at the intersection of sumoylation and the RanGTPase cycle. ". Nucleus. 2012. PMID 22925898.
• "Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores. ". J Cell Biol. 2012. PMID 22331847.
• "Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation.". Cancer Res. 2011. PMID 21646468.