RAD51

RAD51
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N0W, 1B22
Dynodwyr
Cyfenwau	RAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
Dynodwyr allanol	OMIM: 179617 HomoloGene: 2155 GeneCards: RAD51
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • DNA binding • ATP-dependent activity, acting on DNA • DNA strand exchange activity • DNA polymerase binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • identical protein binding • endodeoxyribonuclease activity • ATP binding • single-stranded DNA binding • double-stranded DNA binding • GO:0043142 single-stranded DNA helicase activity • chromatin binding • enzyme binding Cydrannau o'r gell • cytoplasm • site of double-strand break • PML body • Cytosgerbwd • nucleoplasm • microtubule organizing center • nuclear chromosome • mitochondrial matrix • nucleolus • mitocondria • perinuclear region of cytoplasm • chromatin • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex • condensed chromosome • condensed nuclear chromosome • lateral element • Cromosom Prosesau biolegol • strand invasion • GO:1903211 mitotic recombination-dependent replication fork processing • reciprocal meiotic recombination • DNA recombination • regulation of double-strand break repair via homologous recombination • DNA metabolic process • positive regulation of DNA ligation • cellular response to camptothecin • double-strand break repair via homologous recombination • cellular response to ionizing radiation • mitotic recombination • protein homooligomerization • GO:0100026 DNA repair • DNA unwinding involved in DNA replication • cellular response to DNA damage stimulus • interstrand cross-link repair • DNA recombinase assembly • negative regulation of G0 to G1 transition • telomere maintenance via recombination • telomere maintenance via telomere lengthening • replication fork processing • GO:0007126 Meiosis • GO:0051178 chromosome organization involved in meiotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5888	n/a
Ensembl	ENSG00000051180	n/a
UniProt	Q06609	n/a
RefSeq (mRNA)	NM_001164269 NM_001164270 NM_002875 NM_133487	n/a
RefSeq (protein)	NP_001157741 NP_001157742 NP_002866 NP_597994	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAD51 yw RAD51 a elwir hefyd yn DNA repair protein RAD51 homolog 1 a RAD51 recombinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAD51.

• RECA
• BRCC5
• FANCR
• MRMV2
• HRAD51
• RAD51A
• HsRad51
• HsT16930

Llyfryddiaeth

• "Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein. ". DNA Repair (Amst). 2017. PMID 29100040.
• "A cell-penetrating antibody inhibits human RAD51 via direct binding. ". Nucleic Acids Res. 2017. PMID 29036688.
• "Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. ". PLoS One. 2017. PMID 28099437.
• "RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells. ". Stem Cell Reports. 2017. PMID 28076755.
• "Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange.". Nat Struct Mol Biol. 2017. PMID 27941862.