RAD1

RAD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3A1J, 3G65, 3GGR
Dynodwyr
Cyfenwau	RAD1, HREC1, RAD1 homolog, RAD1 checkpoint DNA exonuclease
Dynodwyr allanol	OMIM: 603153 HomoloGene: 37695 GeneCards: RAD1
EC number	3.1.11.2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • damaged DNA binding • exodeoxyribonuclease III activity • GO:0001948, GO:0016582 protein binding • 3'-5' exonuclease activity • nuclease activity • exonuclease activity • hydrolase activity Cydrannau o'r gell • intracellular membrane-bounded organelle • Cromosom • nucleoplasm • checkpoint clamp complex • cnewyllyn cell Prosesau biolegol • substantia nigra development • DNA damage checkpoint signaling • cellular response to DNA damage stimulus • DNA replication • meiotic recombination checkpoint signaling • cellular response to ionizing radiation • nucleic acid phosphodiester bond hydrolysis • regulation of signal transduction by p53 class mediator • GO:0100026 DNA repair Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5810	n/a
Ensembl	ENSG00000113456	n/a
UniProt	O60671	n/a
RefSeq (mRNA)	NM_001033673 NM_002853 NM_133282 NM_133377	n/a
RefSeq (protein)	NP_002844	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAD1 yw RAD1 a elwir hefyd yn RAD1 checkpoint DNA exonuclease (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAD1.

• REC1
• HRAD1

Llyfryddiaeth

• "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. ". Genomics. 1998. PMID 9828137.
• "Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women. ". Int J Biol Markers. 2016. PMID 26954070.
• "RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. ". Genomics. 1998. PMID 9828139.
• "Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation. ". Oncogene. 2004. PMID 15122316.
• "Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex.". J Biol Chem. 2001. PMID 11340080.