RAC2

RAC2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DS6, 2W2T, 2W2V, 2W2X
Dynodwyr
Cyfenwau	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C, IMD73A
Dynodwyr allanol	OMIM: 602049 HomoloGene: 55699 GeneCards: RAC2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GTP binding • protein kinase regulator activity • GO:0006184 GTPase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • phagocytic vesicle membrane • nuclear envelope • bilen • focal adhesion • Cellbilen • Microffilament • extracellular exosome • lamellipodium • intracellular anatomical structure Prosesau biolegol • regulation of respiratory burst • lymphocyte aggregation • regulation of T cell proliferation • positive regulation of protein targeting to mitochondrion • regulation of hydrogen peroxide metabolic process • actin filament organization • regulation of cell-substrate adhesion • regulation of neutrophil migration • bone resorption • platelet activation • chemotaxis • cell projection assembly • positive regulation of cell population proliferation • regulation of mast cell chemotaxis • positive regulation of neutrophil chemotaxis • regulation of mast cell degranulation • regulation of protein kinase activity • positive regulation of lamellipodium assembly • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization • GO:0072468 signal transduction • small GTPase mediated signal transduction • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5880	n/a
Ensembl	ENSG00000128340	n/a
UniProt	P15153	n/a
RefSeq (mRNA)	NM_002872	n/a
RefSeq (protein)	NP_002863	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAC2 yw RAC2 a elwir hefyd yn Rac family small GTPase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAC2.

• Gx
• EN-7
• HSPC022
• p21-Rac2

Llyfryddiaeth

• "Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. ". Immunity. 2011. PMID 22018470.
• "An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases. ". Mol Biol Evol. 2011. PMID 21680873.
• "Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2. ". PLoS One. 2015. PMID 26016997.
• "RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency. ". J Allergy Clin Immunol. 2015. PMID 25512081.
• "Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.". Blood. 2012. PMID 22411871.