RAB7A

RAB7A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1T91, 1YHN, 3LAW
Dynodwyr
Cyfenwau	RAB7A, PRO2706, RAB7, member RAS oncogene family, CMT2B
Dynodwyr allanol	OMIM: 602298 HomoloGene: 3408 GeneCards: RAB7A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GTP binding • GO:0001948, GO:0016582 protein binding • retromer complex binding • GO:0006184 GTPase activity • GDP binding Cydrannau o'r gell • cytoplasm • phagophore assembly site membrane • endosome • phagocytic vesicle membrane • Golgi apparatus • late endosome • bilen • late endosome membrane • extrinsic component of lysosome membrane • lipid droplet • melanosome membrane • retromer complex • lysosomal membrane • autophagosome membrane • phagocytic vesicle • lysosome • extracellular exosome • GO:0016023 cytoplasmic vesicle • cytosol • Cellbilen • endosome membrane • secretory granule membrane • terminal bouton • alveolar lamellar body • vacuolar membrane • intracellular anatomical structure Prosesau biolegol • protein to membrane docking • protein targeting to lysosome • lipophagy • viral release from host cell • GO:1903364 positive regulation of protein catabolic process • phagosome-lysosome fusion • endocytosis • antigen processing and presentation of exogenous peptide antigen via MHC class II • lipid metabolism • endosome to lysosome transport • phagosome acidification • autophagy • lipid catabolic process • phagosome maturation • early endosome to late endosome transport • retrograde transport, endosome to Golgi • protein transport • positive regulation of exosomal secretion • epidermal growth factor catabolic process • positive regulation of viral process • neutrophil degranulation • negative regulation of exosomal secretion • negative regulation of intralumenal vesicle formation • autophagosome assembly • bone resorption • GO:0015915 transport • intracellular protein transport • Rab protein signal transduction • small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7879	n/a
Ensembl	ENSG00000075785	n/a
UniProt	P51149	n/a
RefSeq (mRNA)	NM_004637	n/a
RefSeq (protein)	NP_004628	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAB7A yw RAB7A a elwir hefyd yn Ras-related protein Rab-7a a RAB7A, member RAS oncogene family (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAB7A.

• RAB7
• PRO2706

Llyfryddiaeth

• "HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation. ". J Cell Sci. 2015. PMID 25770103.
• "The small GTPase Rab7 as a central regulator of hepatocellular lipophagy. ". Hepatology. 2015. PMID 25565581.
• "Rab7A regulates tau secretion. ". J Neurochem. 2017. PMID 28222213.
• "A modification switch on a molecular switch: Phosphoregulation of Rab7 during endosome maturation. ". Small GTPases. 2016. PMID 27070490.
• "Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages.". Sci Rep. 2015. PMID 26541268.