RAB5B

RAB5B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HEI
Dynodwyr
Cyfenwau	RAB5B, Rab-5B, member RAS oncogene family
Dynodwyr allanol	OMIM: 179514 HomoloGene: 104027 GeneCards: RAB5B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GDP binding • GTP binding • GTP-dependent protein binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity Cydrannau o'r gell • endosome • bilen • melanosome • endocytic vesicle • intracellular anatomical structure • early endosome • extracellular exosome • Cellbilen • secretory granule membrane • early endosome membrane • intracellular membrane-bounded organelle • anchored component of synaptic vesicle membrane Prosesau biolegol • regulation of endocytosis • antigen processing and presentation • endosome organization • plasma membrane to endosome transport • protein transport • neutrophil degranulation • GO:0015915 transport • intracellular protein transport • Rab protein signal transduction • endocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5869	n/a
Ensembl	ENSG00000111540	n/a
UniProt	P61020	n/a
RefSeq (mRNA)	NM_001252036 NM_001252037 NM_002868	n/a
RefSeq (protein)	NP_001238965 NP_001238966 NP_002859	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAB5B yw RAB5B a elwir hefyd yn RAB5B, member RAS oncogene family (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.2.

Llyfryddiaeth

• "An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. ". J Biochem. 2015. PMID 25605758.
• "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. ". FEBS Lett. 1999. PMID 10403367.
• "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments. ". Biochem Biophys Res Commun. 2007. PMID 17927960.
• "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. ". J Clin Invest. 1992. PMID 1541686.
• "G2385R and I2020T Mutations Increase LRRK2 GTPase Activity.". Biomed Res Int. 2016. PMID 27314038.