RAB5A

RAB5A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N6H, 1N6I, 1N6K, 1N6L, 1N6N, 1N6O, 1N6P, 1N6R, 1R2Q, 1TU3, 1TU4, 3MJH, 4Q9U
Dynodwyr
Cyfenwau	RAB5A, RAB5, member RAS oncogene family
Dynodwyr allanol	OMIM: 179512 HomoloGene: 68142 GeneCards: RAB5A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GDP binding • GTP binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • guanyl nucleotide binding Cydrannau o'r gell • cytoplasm • axon terminus • endosome • cell projection • bilen • synaptic vesicle • melanosome • ruffle • Cellbilen • endocytic vesicle • axon • neuronal cell body • terminal bouton • dendrite • somatodendritic compartment • early endosome • phagocytic vesicle • actin cytoskeleton • membrane raft • cytoplasmic side of early endosome membrane • extracellular exosome • GO:0016023 cytoplasmic vesicle • phagocytic vesicle membrane • cytosol • endosome membrane • clathrin-coated vesicle membrane • early endosome membrane • early phagosome • postsynaptic early endosome • anchored component of synaptic vesicle membrane Prosesau biolegol • regulation of endocytosis • regulation of filopodium assembly • endocytosis • blood coagulation • receptor internalization involved in canonical Wnt signaling pathway • regulation of autophagosome assembly • synaptic vesicle recycling • early endosome to late endosome transport • GO:0015915 transport • protein transport • positive regulation of exocytosis • regulation of synaptic vesicle exocytosis • regulation of endosome size • viral RNA genome replication • ffagocytosis • phosphatidylinositol biosynthetic process • membrane organization • post-translational protein modification • intracellular protein transport • Rab protein signal transduction • regulation of long-term neuronal synaptic plasticity • amyloid-beta clearance by transcytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5868	n/a
Ensembl	ENSG00000144566	n/a
UniProt	P20339	n/a
RefSeq (mRNA)	NM_004162 NM_001292048	n/a
RefSeq (protein)	NP_001278977 NP_004153	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAB5A yw RAB5A a elwir hefyd yn RAB5A, member RAS oncogene family (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAB5A.

• RAB5

Llyfryddiaeth

• "The Autophagic Process Occurs in Human Bone Metastasis and Implicates Molecular Mechanisms Differently Affected by Rab5a in the Early and Late Stages. ". Int J Mol Sci. 2016. PMID 27023526.
• "Increased expression of Rab5A predicts metastasis and poor prognosis in colorectal cancer patients. ". Int J Clin Exp Pathol. 2015. PMID 26261586.
• "Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region. ". Biochim Biophys Acta. 2017. PMID 28455099.
• "Expression of Rab5a correlates with tumor progression in pancreatic carcinoma. ". Virchows Arch. 2017. PMID 28243729.
• "Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations.". J Enzyme Inhib Med Chem. 2017. PMID 28090783.