QKI

QKI
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4JVH
Dynodwyr
Cyfenwau	QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
Dynodwyr allanol	OMIM: 609590 HomoloGene: 11059 GeneCards: QKI
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • mRNA binding • RNA binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • synapse Prosesau biolegol • cell differentiation • mRNA transport • mRNA processing • vasculogenesis • multicellular organism development • axon ensheathment • muscle cell differentiation • GO:1901313 positive regulation of gene expression • long-chain fatty acid biosynthetic process • RNA splicing • spermatid development • myelination • 3'-UTR-mediated mRNA destabilization • regulation of translation • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9444	n/a
Ensembl	ENSG00000112531	n/a
UniProt	Q96PU8	n/a
RefSeq (mRNA)	NM_001301085 NM_006775 NM_206853 NM_206854 NM_206855	n/a
RefSeq (protein)	NP_001288014 NP_006766 NP_996735 NP_996736 NP_996737	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn QKI yw QKI a elwir hefyd yn Protein quaking (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q26.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn QKI.

• QK
• Hqk
• QK1
• QK3
• hqkI

Llyfryddiaeth

• "QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis. ". Oncotarget. 2016. PMID 27092877.
• "Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. ". Nat Commun. 2016. PMID 27029405.
• "Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer. ". Anticancer Res. 2017. PMID 28179294.
• "Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. ". Nat Genet. 2017. PMID 27841882.
• "A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.". Mol Oncol. 2016. PMID 27555542.