PYCR1

PYCR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GER, 2GR9, 2GRA, 2IZZ
Dynodwyr
Cyfenwau	PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1
Dynodwyr allanol	OMIM: 179035 HomoloGene: 56002 GeneCards: PYCR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • GO:0001948, GO:0016582 protein binding • pyrroline-5-carboxylate reductase activity • identical protein binding Cydrannau o'r gell • mitochondrial matrix • mitocondria Prosesau biolegol • regulation of mitochondrial membrane potential • cellular response to oxidative stress • negative regulation of hydrogen peroxide-induced cell death • cellular amino acid biosynthetic process • L-proline biosynthetic process • proline biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5831	n/a
Ensembl	ENSG00000183010	n/a
UniProt	P32322	n/a
RefSeq (mRNA)	NM_001282279 NM_001282280 NM_001282281 NM_006907 NM_153824 NM_001330523	n/a
RefSeq (protein)	NP_001269208 NP_001269209 NP_001269210 NP_001317452 NP_008838 NP_722546	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PYCR1 yw PYCR1 a elwir hefyd yn Pyrroline-5-carboxylate reductase 1, mitochondrial a Pyrroline-5-carboxylate reductase 1, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PYCR1.

• P5C
• P5CR
• PRO3
• PYCR
• PIG45
• PP222
• ARCL2B
• ARCL3B

Llyfryddiaeth

• "Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer. ". Med Oncol. 2017. PMID 28078560.
• "Human pyrroline-5-carboxylate reductase (PYCR1) acts on Δ(1)-piperideine-6-carboxylate generating L-pipecolic acid. ". J Inherit Metab Dis. 2014. PMID 24431009.
• "Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers. ". Carcinogenesis. 2017. PMID 28379297.
• "Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. ". J Biol Chem. 2017. PMID 28258219.
• "Effect of R119G Mutation on Human P5CR1 Dynamic Property and Enzymatic Activity.". Biomed Res Int. 2017. PMID 28194412.