PYCARD

PYCARD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UCP, 2KN6, 3J63, 5H8O
Dynodwyr
Cyfenwau	PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Dynodwyr allanol	OMIM: 606838 HomoloGene: 8307 GeneCards: PYCARD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • interleukin-6 receptor binding • BMP receptor binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • cysteine-type endopeptidase activity involved in apoptotic process • Pyrin domain binding • cysteine-type endopeptidase activator activity involved in apoptotic process • myosin I binding • tropomyosin binding • protease binding • transmembrane transporter binding • protein dimerization activity • cysteine-type endopeptidase activity Cydrannau o'r gell • cytoplasm • NLRP3 inflammasome complex • NLRP1 inflammasome complex • AIM2 inflammasome complex • nucleolus • Reticwlwm endoplasmig • mitocondria • IkappaB kinase complex • cnewyllyn cell • secretory granule lumen • azurophil granule lumen • extracellular region • cytosol • GO:0009327 protein-containing complex • neuronal cell body • Golgi membrane • Golgi apparatus • bilen Prosesau biolegol • positive regulation of cysteine-type endopeptidase activity • regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of intrinsic apoptotic signaling pathway • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of adaptive immune response • GO:0051636 defense response to Gram-negative bacterium • immune system process • cellular response to tumor necrosis factor • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of DNA-binding transcription factor activity • tumor necrosis factor-mediated signaling pathway • positive regulation of JNK cascade • negative regulation of interferon-beta production • negative regulation of I-kappaB kinase/NF-kappaB signaling • myeloid dendritic cell activation • positive regulation of T cell activation • defense response to virus • cellular response to interleukin-1 • positive regulation of apoptotic process • positive regulation of tumor necrosis factor production • positive regulation of release of cytochrome c from mitochondria • negative regulation of protein serine/threonine kinase activity • positive regulation of extrinsic apoptotic signaling pathway • inflammatory response • cellular response to lipopolysaccharide • negative regulation of NF-kappaB transcription factor activity • GO:0072468 signal transduction • GO:0097285 apoptotic process • innate immune response • neutrophil degranulation • positive regulation of NF-kappaB transcription factor activity • activation of innate immune response • myeloid dendritic cell activation involved in immune response • positive regulation of antigen processing and presentation of peptide antigen via MHC class II • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of actin filament polymerization • regulation of protein stability • positive regulation of interferon-gamma production • positive regulation of interleukin-6 production • positive regulation of activated T cell proliferation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • macropinocytosis • positive regulation of phagocytosis • positive regulation of ERK1 and ERK2 cascade • positive regulation of T cell migration • positive regulation of defense response to virus by host • intrinsic apoptotic signaling pathway in response to DNA damage • response to bacterium • regulation of autophagy • interleukin-1 beta production • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of inflammatory response • protein homooligomerization • activation of cysteine-type endopeptidase activity • negative regulation of cytokine production involved in inflammatory response • proteolysis • positive regulation of interleukin-1 beta production Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	29108	n/a
Ensembl	ENSG00000103490	n/a
UniProt	Q9ULZ3	n/a
RefSeq (mRNA)	NM_145183 NM_013258 NM_145182	n/a
RefSeq (protein)	NP_037390 NP_660183	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PYCARD yw PYCARD a elwir hefyd yn PYD and CARD domain containing (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PYCARD.

• ASC
• TMS
• TMS1
• CARD5
• TMS-1

Llyfryddiaeth

• "ASC provides a potential link between depression and inflammatory disorders: A clinical study of depressed Iranian medical students. ". Nord J Psychiatry. 2016. PMID 26750863.
• "Methylation of Apoptosis-Associated Speck-Like Protein With a Caspase Recruitment Domain and Outcomes in Heart Failure. ". J Card Fail. 2016. PMID 26700661.
• "ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication. ". PLoS One. 2017. PMID 28056049.
• "Silencing of ASC in Cutaneous Squamous Cell Carcinoma. ". PLoS One. 2016. PMID 27768771.
• "A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.". J Exp Med. 2016. PMID 27069117.