PTPRT

PTPRT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OOQ
Dynodwyr
Cyfenwau	PTPRT, RPTPrho, protein tyrosine phosphatase, receptor type T, protein tyrosine phosphatase receptor type T, RPTP-rho, R-PTP-T
Dynodwyr allanol	OMIM: 608712 HomoloGene: 56924 GeneCards: PTPRT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein tyrosine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • beta-catenin binding • GO:0001948, GO:0016582 protein binding • phosphoprotein phosphatase activity • hydrolase activity • alpha-catenin binding • cadherin binding • delta-catenin binding • gamma-catenin binding • transmembrane receptor protein tyrosine phosphatase activity • protein phosphatase binding • protein homodimerization activity • STAT family protein binding Cydrannau o'r gell • integral component of membrane • cell surface • Cellbilen • bilen • integral component of plasma membrane Prosesau biolegol • GO:0016576 protein dephosphorylation • cell adhesion • GO:0072468 signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • transmembrane receptor protein tyrosine kinase signaling pathway • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation • negative regulation of cell migration • cellular response to interleukin-6 • negative regulation of receptor signaling pathway via STAT • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11122	n/a
Ensembl	ENSG00000196090	n/a
UniProt	O14522	n/a
RefSeq (mRNA)	NM_007050 NM_133170 NM_001394024 NM_001394025 NM_001394026	n/a
RefSeq (protein)	NP_008981 NP_573400	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRT yw PTPRT a elwir hefyd yn Protein tyrosine phosphatase, receptor type T (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q12-q13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRT.

• RPTPrho

Llyfryddiaeth

• "Tumour suppressor function of protein tyrosine phosphatase receptor-T. ". Biosci Rep. 2011. PMID 21517784.
• "Mutational analysis of PTPRT phosphatase domains in common human cancers. ". APMIS. 2007. PMID 17223850.
• "Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis. ". Leuk Res. 2016. PMID 27244256.
• "The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population. ". Cell Physiol Biochem. 2015. PMID 25967969.
• "Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.". PLoS One. 2012. PMID 22389709.