PTPRS

PTPRS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FH7, 2YD2, 2YD3, 2YD9, 4BPC, 4PBX
Dynodwyr
Cyfenwau	PTPRS, PTPSIGMA, protein tyrosine phosphatase, receptor type S, R-PTP-S, R-PTP-sigma, protein tyrosine phosphatase receptor type S
Dynodwyr allanol	OMIM: 601576 HomoloGene: 20626 GeneCards: PTPRS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0098519, GO:0098518 phosphatase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • heparin binding • chondroitin sulfate binding • heparan sulfate proteoglycan binding Cydrannau o'r gell • integral component of membrane • integral component of plasma membrane • extracellular exosome • bilen • Cellbilen • integral component of synaptic vesicle membrane • integral component of postsynaptic density membrane • GO:0097483, GO:0097481 postsynaptic density • cell junction • axon • synaptic vesicle membrane • GO:0016023 cytoplasmic vesicle • cell projection • neuron projection • perikaryon • synapse • postsynaptic membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse • integral component of presynaptic membrane Prosesau biolegol • cell adhesion • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:0016576 protein dephosphorylation • negative regulation of interferon-alpha production • negative regulation of interferon-beta production • negative regulation of toll-like receptor 9 signaling pathway • negative regulation of neuron projection development • spinal cord development • cerebellum development • hippocampus development • cerebral cortex development • corpus callosum development • negative regulation of axon extension • peptidyl-tyrosine dephosphorylation • negative regulation of collateral sprouting • negative regulation of axon regeneration • negative regulation of dendritic spine development • establishment of endothelial intestinal barrier • modulation of chemical synaptic transmission • synapse organization • regulation of postsynaptic density assembly • synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5802	n/a
Ensembl	ENSG00000105426	n/a
UniProt	Q13332	n/a
RefSeq (mRNA)	NM_002850 NM_130853 NM_130854 NM_130855 NM_001394011 NM_001394012 NM_001394013	n/a
RefSeq (protein)	NP_002841 NP_570923 NP_570924 NP_570925	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRS yw PTPRS a elwir hefyd yn Receptor-type tyrosine-protein phosphatase S a Protein tyrosine phosphatase, receptor type S (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRS.

• R-PTP-S
• PTPSIGMA
• R-PTP-sigma

Llyfryddiaeth

• "Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. ". Eur J Endocrinol. 2007. PMID 17893260.
• "Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin. ". J Cell Biochem. 2006. PMID 16552719.
• "Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. ". Proc Natl Acad Sci U S A. 2011. PMID 22065749.
• "Identification of PTPsigma as an autophagic phosphatase. ". J Cell Sci. 2011. PMID 21303930.
• "A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.". Sci Signal. 2010. PMID 20179269.