PTPRO

PTPRO
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G59, 2GJT
Dynodwyr
Cyfenwau	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O, protein tyrosine phosphatase receptor type O
Dynodwyr allanol	OMIM: 600579 HomoloGene: 21564 GeneCards: PTPRO
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • protein homodimerization activity • GO:0098519, GO:0098518 phosphatase activity • Wnt-protein binding • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity Cydrannau o'r gell • integral component of membrane • lateral plasma membrane • bilen • growth cone • Cellbilen • dendritic spine • integral component of plasma membrane • axon • apical plasma membrane • neuron projection • extracellular exosome • lamellipodium • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic density membrane Prosesau biolegol • negative regulation of cell-substrate adhesion • negative regulation of neuron projection development • monocyte chemotaxis • negative regulation of retinal ganglion cell axon guidance • regulation of glomerular filtration • slit diaphragm assembly • GO:0016576 protein dephosphorylation • glomerulus development • axon guidance • GO:0000767 cell morphogenesis • glomerular visceral epithelial cell differentiation • peptidyl-tyrosine dephosphorylation • negative regulation of glomerular filtration • negative regulation of canonical Wnt signaling pathway • lamellipodium assembly • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:1904739 regulation of synapse organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5800	n/a
Ensembl	ENSG00000151490	n/a
UniProt	Q16827	n/a
RefSeq (mRNA)	NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671	n/a
RefSeq (protein)	NP_002839 NP_109592 NP_109593 NP_109594 NP_109595 NP_109596	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRO yw PTPRO a elwir hefyd yn Protein tyrosine phosphatase, receptor type O (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p12.3|12p13-p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRO.

• NPHS6
• PTPU2
• GLEPP1
• PTP-OC
• PTP-U2
• PTPROT
• R-PTP-O

Llyfryddiaeth

• "Expression, purification, and characterization of human osteoclastic protein-tyrosine phosphatase catalytic domain in Escherichia coli. ". Protein Expr Purif. 2015. PMID 25462809.
• "The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling. ". Oncotarget. 2014. PMID 25301722.
• "Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. ". Am J Respir Crit Care Med. 2017. PMID 28199135.
• "PTPRO-associated hepatic stellate cell activation plays a critical role in liver fibrosis. ". Cell Physiol Biochem. 2015. PMID 25633279.
• "PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model.". Leukemia. 2015. PMID 25482129.