PTPRN

PTPRN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I1Y, 2QT7, 3N01, 3N4W, 3NG8, 3NP5
Dynodwyr
Cyfenwau	PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N, protein tyrosine phosphatase receptor type N
Dynodwyr allanol	OMIM: 601773 HomoloGene: 48142 GeneCards: PTPRN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • spectrin binding • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • transcription factor binding • ubiquitin-like protein ligase binding • GTPase binding • GO:0098519, GO:0098518 phosphatase activity • hydrolase activity Cydrannau o'r gell • axon terminus • integral component of membrane • perikaryon • endosome • Golgi apparatus • cell projection • bilen • synaptic vesicle • Cellbilen • transport vesicle membrane • synapse • secretory granule • axon • cell junction • neuronal cell body • GO:0016023 cytoplasmic vesicle • cnewyllyn cell Prosesau biolegol • luteinization • cytokine-mediated signaling pathway • GO:0001315 response to reactive oxygen species • insulin secretion • response to glucose • response to estrogen • response to insulin • response to cAMP • dense core granule maturation • insulin secretion involved in cellular response to glucose stimulus • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of type B pancreatic cell proliferation • peptidyl-tyrosine dephosphorylation • GO:0016576 protein dephosphorylation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5798	n/a
Ensembl	ENSG00000054356	n/a
UniProt	Q16849	n/a
RefSeq (mRNA)	NM_001199763 NM_001199764 NM_002846	n/a
RefSeq (protein)	NP_001186692 NP_001186693 NP_002837	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRN yw PTPRN a elwir hefyd yn Receptor-type tyrosine-protein phosphatase-like N a Protein tyrosine phosphatase, receptor type N (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRN.

• IA2
• IA-2
• ICA512
• R-PTP-N
• IA-2/PTP

Llyfryddiaeth

• "The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes. ". Diabetes. 2013. PMID 22966073.
• "Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain. ". PLoS One. 2011. PMID 21935384.
• "Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application. ". BMC Biotechnol. 2016. PMID 27881117.
• "Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. ". Diabetologia. 2016. PMID 26564179.
• "IA-2 autoantibody affinity in children at risk for type 1 diabetes.". Clin Immunol. 2012. PMID 23110943.