PTPN6

PTPN6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ
Dynodwyr
Cyfenwau	PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6, protein tyrosine phosphatase non-receptor type 6
Dynodwyr allanol	OMIM: 176883 HomoloGene: 56589 GeneCards: PTPN6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • SH3 domain binding • GO:0098519, GO:0098518 phosphatase activity • phosphotyrosine residue binding • SH2 domain binding • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity • protein kinase binding • cell adhesion molecule binding • protein tyrosine phosphatase activity • phosphorylation-dependent protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • cell-cell junction • alpha-beta T cell receptor complex • nucleolus • extracellular exosome • cnewyllyn cell • extracellular region • specific granule lumen • tertiary granule lumen • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • B cell receptor signaling pathway • megakaryocyte development • G protein-coupled receptor signaling pathway • cell differentiation • GO:0007243 intracellular signal transduction • regulation of release of sequestered calcium ion into cytosol • abortive mitotic cell cycle • T cell costimulation • GO:0016576 protein dephosphorylation • platelet formation • negative regulation of T cell receptor signaling pathway • platelet activation • negative regulation of humoral immune response mediated by circulating immunoglobulin • regulation of G1/S transition of mitotic cell cycle • negative regulation of T cell proliferation • regulation of type I interferon-mediated signaling pathway • negative regulation of peptidyl-tyrosine phosphorylation • negative regulation of MAP kinase activity • hematopoietic progenitor cell differentiation • positive regulation of cell population proliferation • negative regulation of MAPK cascade • regulation of ERK1 and ERK2 cascade • negative regulation of B cell receptor signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of cell adhesion mediated by integrin • cell population proliferation • platelet aggregation • regulation of B cell differentiation • leukocyte migration • natural killer cell mediated cytotoxicity • negative regulation of cell population proliferation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:0097285 apoptotic process • neutrophil degranulation • peptidyl-tyrosine dephosphorylation • cytokine-mediated signaling pathway • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5777	n/a
Ensembl	ENSG00000111679	n/a
UniProt	P29350	n/a
RefSeq (mRNA)	NM_002831 NM_080548 NM_080549	n/a
RefSeq (protein)	NP_002822 NP_536858 NP_536859	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPN6 yw PTPN6 a elwir hefyd yn Protein tyrosine phosphatase, non-receptor type 6 a Tyrosine-protein phosphatase non-receptor type 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPN6.

• HCP
• HCPH
• SHP1
• SHP-1
• HPTP1C
• PTP-1C
• SHP-1L
• SH-PTP1

Llyfryddiaeth

• "Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma. ". Oncol Rep. 2017. PMID 27959415.
• "The NF-kB regulates the SHP-1 expression in monocytes in congestive heart failure. ". Front Biosci (Landmark Ed). 2017. PMID 27814644.
• "Shp1 function in myeloid cells. ". J Leukoc Biol. 2017. PMID 28606940.
• "Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia. ". Br J Haematol. 2017. PMID 28480959.
• "Shp1 positively regulates EGFR signaling by controlling EGFR protein expression in mammary epithelial cells.". Biochem Biophys Res Commun. 2017. PMID 28416389.