PTPN3

PTPN3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2B49, 4QUM, 4QUN, 4RH5, 4RH9, 4RHG, 4RI4, 4RI5, 4S0G
Dynodwyr
Cyfenwau	PTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
Dynodwyr allanol	OMIM: 176877 HomoloGene: 74451 GeneCards: PTPN3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sodium channel regulator activity • phosphoprotein phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • phosphotyrosine residue binding • ATPase binding • cytoskeletal protein binding • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • hydrolase activity Cydrannau o'r gell • cytoplasm • bilen • cytoplasmic side of plasma membrane • Cytosgerbwd • Cellbilen Prosesau biolegol • regulation of membrane depolarization during action potential • GO:0016576 protein dephosphorylation • liver regeneration • regulation of sodium ion transmembrane transporter activity • negative regulation of membrane protein ectodomain proteolysis • negative regulation of mitotic cell cycle • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation • negative regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5774	n/a
Ensembl	ENSG00000070159	n/a
UniProt	P26045	n/a
RefSeq (mRNA)	NM_001145368 NM_001145369 NM_001145370 NM_001145371 NM_001145372 NM_002829	n/a
RefSeq (protein)	NP_001138840 NP_001138841 NP_001138842 NP_001138843 NP_001138844 NP_002820	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPN3 yw PTPN3 a elwir hefyd yn Protein tyrosine phosphatase, non-receptor type 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPN3.

• PTPH1
• PTP-H1

Llyfryddiaeth

• "Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. ". Int J Cancer. 1993. PMID 8253532.
• "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. ". J Gastroenterol. 1994. PMID 7874267.
• "Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. ". Structure. 2015. PMID 25728925.
• "Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. ". Gastroenterology. 2014. PMID 24503127.
• "Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3.". J Biomed Sci. 2007. PMID 17588219.